D(4) dopamine receptor (DRD4)

About D(4) dopamine receptor

D(4) dopamine receptor (DRD4) is a protein from Homo sapiens identified by UniProt accession P21917, 419 residues long. MolForge cross-references it against 0 known binders and 257 disease associations.

Target properties

Protein name	D(4) dopamine receptor
UniProt accession	P21917
Gene	DRD4
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (257)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.62
bipolar disorder · score 0.61
Parkinson disease · score 0.61
restless legs syndrome · score 0.60
schizoaffective disorder · score 0.60
Agitation · score 0.60
unipolar depression · score 0.59
psychosis · score 0.58
delirium · score 0.58
depressive disorder · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21917-F1	alphafold	PREDICTED	77.12	—

Amino-acid sequence (419 residues)

MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGAAALVG GVLLIGAVLA GNSLVCVSVA TERALQTPTN SFIVSLAAAD LLLALLVLPL FVYSEVQGGA WLLSPRLCDA LMAMDVMLCT ASIFNLCAIS VDRFVAVAVP LRYNRQGGSR RQLLLIGATW LLSAAVAAPV LCGLNDVRGR DPAVCRLEDR DYVVYSSVCS FFLPCPLMLL LYWATFRGLQ RWEVARRAKL HGRAPRRPSG PGPPSPTPPA PRLPQDPCGP DCAPPAPGLP RGPCGPDCAP AAPSLPQDPC GPDCAPPAPG LPPDPCGSNC APPDAVRAAA LPPQTPPQTR RRRRAKITGR ERKAMRVLPV VVGAFLLCWT PFFVVHITQA LCPACSVPPR LVSAVTWLGY VNSALNPVIY TVFNAEFRNV FRKALRACC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards