Amisulpride

Dopamine-2 Receptor Antagonist — NERVOUS SYSTEM

Key facts

Amisulpride is an ofp drug in the Dopamine-2 Receptor Antagonist class catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1986. Its mechanism of action is classified as Dopamine D2 Antagonists. DrugCentral lists 12 molecular targets, including DRD2, DRD3 and HTR7. Recorded indications include Chronic schizophrenia and Postoperative nausea and vomiting.

• Approval status: ofp (first approved 1986 by the YEAR INTRODUCED).
• Drug class: Dopamine-2 Receptor Antagonist.
• Mechanism of action: Dopamine D2 Antagonists.
• Molecular targets: DRD2, DRD3, HTR7 and HTR2B (12 listed in DrugCentral).
• Indications: Chronic schizophrenia and Postoperative nausea and vomiting.
• ATC code: N05AL05 (Benzamides).
• Molecular formula: C17H27N3O4S; molecular weight 369.49 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Chronic schizophrenia
• Postoperative nausea and vomiting

Off-label uses (1)

• Dysthymia

Mechanism & targets

• Mechanism of action (MoA): Dopamine D2 Antagonists
• Established pharmacologic class: Dopamine-2 Receptor Antagonist

Molecular targets (12)

Target	Gene	Action	Activity
D(2) dopamine receptor	DRD2	antagonist	Ki 8.55
D(3) dopamine receptor	DRD3	antagonist	Ki 8.49
5-hydroxytryptamine receptor 7	HTR7	unknown	Ki 7.94
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 7.89
D(3) dopamine receptor	Drd3	antagonist	Ki 7.40
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 5.95
5-hydroxytryptamine receptor 1D	HTR1D	unknown	Ki 5.87
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 5.81
5-hydroxytryptamine receptor 1B	HTR1B	unknown	Ki 5.76
D(4) dopamine receptor	DRD4	unknown	Ki 5.62
5-hydroxytryptamine receptor 6	HTR6	unknown	Ki 5.38
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.08

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2020-02-26	FDA	—	ACACIA PHARMA LTD
1986-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05AL05	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Benzamides

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Extrapyramidal disorder	841.1
Akathisia	824.7
Antipsychotic drug level below therapeutic	736.5
Schizophrenia	604.7
Disinhibition	579.5
Euphoric mood	524.8
Therapeutic product effect variable	521.2
Hyperprolactinaemia	516.0
Obsessive-compulsive disorder	510.8
Neuroleptic malignant syndrome	489.8
Antipsychotic drug level increased	415.1
Suicide attempt	409.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Amisulpride is on its molecule page.

• Molecular formula: C₁₇H₂₇N₃O₄S
• Molecular weight: 369.49 g/mol
• CAS number: —
• InChIKey: NTJOBXMMWNYJFB-UHFFFAOYSA-N
• PubChem CID: 2159

CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Amisulpride used for?

DrugCentral lists the following indications for Amisulpride: Chronic schizophrenia and Postoperative nausea and vomiting.

How does Amisulpride work?

Amisulpride is classified as Dopamine D2 Antagonists; its molecular targets in DrugCentral include DRD2 (antagonist), DRD3 (antagonist), HTR7 and HTR2B.

When was Amisulpride first approved?

Amisulpride was first approved by the YEAR INTRODUCED in 1986.

What drug class does Amisulpride belong to?

Amisulpride is in the Dopamine-2 Receptor Antagonist class.

What is the chemical formula of Amisulpride?

Amisulpride has the molecular formula C17H27N3O4S and a molecular weight of 369.49 g/mol.

Sources

• DrugCentral drug card 179 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL243712 — compound record and bioactivity
• PubChem CID 2159 — chemical identifiers
• DrugBank DB06288 — drug record
• FDA UNII 8110R61I4U — substance identity
• DailyMed: FDA labels for Amisulpride — current prescribing information (label search)
• UniProt P14416 (DRD2) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P34969 (HTR7) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P28221 (HTR1D) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.