5-hydroxytryptamine receptor 1B (HTR1B)

About 5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B (HTR1B) is a protein from Homo sapiens identified by UniProt accession P28222, 390 residues long. MolForge cross-references it against 0 known binders and 182 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 1B
UniProt accession	P28222
Gene	HTR1B
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (182)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.61
schizophrenia · score 0.61
Headache · score 0.53
cardiovascular disease · score 0.53
pain · score 0.51
mental or behavioural disorder · score 0.50
schizoaffective disorder · score 0.50
migraine with aura · score 0.50
migraine without aura · score 0.50
post operative nausea and vomiting · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28222-F1	alphafold	PREDICTED	79.18	—

Amino-acid sequence (390 residues)

MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards