5-hydroxytryptamine receptor 6 (HTR6)

About 5-hydroxytryptamine receptor 6

5-hydroxytryptamine receptor 6 (HTR6) is a protein from Homo sapiens identified by UniProt accession P50406, 440 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 6
UniProt accession	P50406
Gene	HTR6
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (85)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.61
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
depressive disorder · score 0.43
Alzheimer disease · score 0.39
psychosis · score 0.38
unipolar depression · score 0.37
mental or behavioural disorder · score 0.37
obesity · score 0.37
Nausea and vomiting · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50406-F1	alphafold	PREDICTED	72.65	—

Amino-acid sequence (440 residues)

MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards