5-hydroxytryptamine receptor 2B (HTR2B)

About 5-hydroxytryptamine receptor 2B

5-hydroxytryptamine receptor 2B (HTR2B) is a protein from Homo sapiens identified by UniProt accession P41595, 481 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 2B
UniProt accession	P41595
Gene	HTR2B
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (133)

Diseases linked to this target (Open Targets).

hemorrhage · score 0.60
schizophrenia · score 0.59
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
psychosis · score 0.46
unipolar depression · score 0.46
depressive disorder · score 0.43
migraine disorder · score 0.37
mental or behavioural disorder · score 0.37
obesity · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41595-F1	alphafold	PREDICTED	71.54	—

Amino-acid sequence (481 residues)

MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ GNKLHWAALL ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD LLVGLFVMPI ALLTIMFEAM WPLPLVLCPA WLFLDVLFST ASIMHLCAIS VDRYIAIKKP IQANQYNSRA TAFIKITVVW LISIGIAIPV PIKGIETDVD NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT IHALQKKAYL VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC DSCNQTTLQM LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR ATKSVKTLRK RSSKIYFRNP MAENSKFFKK HGIRNGINPA MYQSPMRLRS STIQSSSIIL LDTLLLTENE GDKTEEQVSY V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards