Methamphetamine

Amphetamine Anorectic — NERVOUS SYSTEM

Key facts

Methamphetamine is an ofp drug in the Amphetamine Anorectic class catalogued in DrugCentral. It was first approved by the FDA in 1943. DrugCentral lists 13 molecular targets, including SLC6A2, SLC6A3 and Taar1. Recorded indications include Attention deficit hyperactivity disorder and Obesity.

• Approval status: ofp (first approved 1943 by the FDA).
• Drug class: Amphetamine Anorectic; Central Nervous System Stimulant.
• Molecular targets: SLC6A2, SLC6A3, Taar1 and Taar1 (13 listed in DrugCentral).
• Indications: Attention deficit hyperactivity disorder and Obesity.
• ATC code: N06BA03 (Centrally acting sympathomimetics).
• Molecular formula: C10H15N; molecular weight 149.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Attention deficit hyperactivity disorder
• Obesity

Contraindications (48)

• Acute exacerbation of asthma
• Aggressive behavior
• Alcoholism
• Anemia
• Anorexia nervosa
• Arteriosclerotic vascular disease
• Bipolar disorder
• Breastfeeding (mother)
• Cardiomyopathy
• Cardiovascular event risk
• Cerebrovascular accident
• Chronic heart failure
• Chronic obstructive lung disease
• Conduction disorder of the heart
• Dependent drug abuse
• Depressive disorder
• Disease of liver
• Disorder of cardiovascular system
• Disorder of coronary artery
• Feeling agitated
• Gilles de la Tourette's syndrome
• Glaucoma
• Hepatic coma
• Hepatic encephalopathy
• Hepatic failure
• Hyperactive behavior
• Hyperammonemia
• Hypertensive disorder
• Hypertensive urgency
• Hyperthyroidism
• + 18 more

Mechanism & targets

• Established pharmacologic class: Amphetamine Anorectic; Central Nervous System Stimulant

Molecular targets (13)

Target	Gene	Action	Activity
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	Ki 7.91
Sodium-dependent dopamine transporter	SLC6A3	inhibitor	Ki 7.61
Trace amine-associated receptor 1	Taar1	unknown	EC50 7.15
Trace amine-associated receptor 1	Taar1	unknown	EC50 6.88
Sodium-dependent serotonin transporter	SLC6A4	inhibitor	Ki 6.13
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.13
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.09
Trace amine-associated receptor 1	TAAR1	agonist	EC50 5.89
Synaptic vesicular amine transporter	Slc18a2	unknown	Ki 5.61
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 5.38
Trace amine-associated receptor 1	TAAR1	unknown	EC50 5.28
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 5.08
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 5.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1943-12-31	FDA	—	RECORDATI RARE

ATC classification

ATC code	Therapeutic hierarchy
N06BA03	NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Centrally acting sympathomimetics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug abuse	15637.5
Toxicity to various agents	5808.4
Completed suicide	1259.9
Respiratory arrest	781.0
Cardiac arrest	639.6
Cardio-respiratory arrest	627.1
Death	504.4
Overdose	464.5
Prescription drug used without a prescription	397.7
Substance abuse	389.1
Substance use disorder	355.1
Exposure to toxic agent	270.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Methamphetamine is on its molecule page.

• Molecular formula: C₁₀H₁₅N
• Molecular weight: 149.24 g/mol
• CAS number: —
• InChIKey: MYWUZJCMWCOHBA-VIFPVBQESA-N
• PubChem CID: 10836

CN[C@@H](C)CC1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Methamphetamine used for?

DrugCentral lists the following indications for Methamphetamine: Attention deficit hyperactivity disorder and Obesity.

How does Methamphetamine work?

Its molecular targets in DrugCentral include SLC6A2 (inhibitor), SLC6A3 (inhibitor), Taar1 and Taar1.

When was Methamphetamine first approved?

Methamphetamine was first approved by the FDA in 1943.

What drug class does Methamphetamine belong to?

Methamphetamine is in the Amphetamine Anorectic class.

What is the chemical formula of Methamphetamine?

Methamphetamine has the molecular formula C10H15N and a molecular weight of 149.24 g/mol.

Sources

• DrugCentral drug card 1732 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200952 — compound record and bioactivity
• PubChem CID 10836 — chemical identifiers
• DrugBank DB01577 — drug record
• FDA UNII 44RAL3456C — substance identity
• DailyMed: FDA labels for Methamphetamine — current prescribing information (label search)
• UniProt P23975 (SLC6A2) — target protein
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P31645 (SLC6A4) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P18825 (ADRA2C) — target protein
• UniProt Q96RJ0 (TAAR1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.