About Sodium-dependent noradrenaline transporter
Sodium-dependent noradrenaline transporter (SLC6A2) is a protein
from Homo sapiens identified by UniProt accession
P23975, 617 residues long.
MolForge cross-references it against 0 known binders and
370 disease associations.
Target properties
| Protein name | Sodium-dependent noradrenaline transporter |
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| UniProt accession | P23975 |
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| Gene | SLC6A2 |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (370)
Diseases linked to this target (Open Targets).
- orthostatic intolerance · score 0.65
- attention deficit hyperactivity disorder · score 0.63
- major depressive disorder · score 0.62
- unipolar depression · score 0.61
- depressive disorder · score 0.61
- fibromyalgia · score 0.61
- Nasal congestion · score 0.60
- seasonal allergic rhinitis · score 0.60
- common cold · score 0.60
- obesity · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23975-F1 | alphafold | PREDICTED | 87.25 | — |
Amino-acid sequence (617 residues)
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL VAQRDIRQFQ LQHWLAI
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