Alpha-2C adrenergic receptor (ADRA2C)

About Alpha-2C adrenergic receptor

Alpha-2C adrenergic receptor (ADRA2C) is a protein from Homo sapiens identified by UniProt accession P18825, 462 residues long. MolForge cross-references it against 0 known binders and 343 disease associations.

Target properties

Protein name	Alpha-2C adrenergic receptor
UniProt accession	P18825
Gene	ADRA2C
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (343)

Diseases linked to this target (Open Targets).

pain · score 0.61
unipolar depression · score 0.60
attention deficit hyperactivity disorder · score 0.60
Nasal congestion · score 0.60
hypotension · score 0.60
seasonal allergic rhinitis · score 0.60
hypertension · score 0.60
delirium · score 0.60
asthma · score 0.60
glaucoma · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18825-F1	alphafold	PREDICTED	72.83	—

Amino-acid sequence (462 residues)

MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS RSVEFFLSRR RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF SYSLYGICRE ACQVPGPLFK FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH ILFRRRRRGF RQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards