About Sodium-dependent serotonin transporter
Sodium-dependent serotonin transporter (SLC6A4) is a protein
from Homo sapiens identified by UniProt accession
P31645, 630 residues long.
MolForge cross-references it against 0 known binders and
537 disease associations.
Target properties
| Protein name | Sodium-dependent serotonin transporter |
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| UniProt accession | P31645 |
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| Gene | SLC6A4 |
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| Organism | Homo sapiens |
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| Length | 630 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (537)
Diseases linked to this target (Open Targets).
- obsessive-compulsive disorder · score 0.69
- major depressive disorder · score 0.64
- unipolar depression · score 0.63
- fibromyalgia · score 0.61
- panic disorder · score 0.61
- post-traumatic stress disorder · score 0.61
- schizophrenia · score 0.61
- depressive disorder · score 0.61
- anxiety · score 0.60
- bipolar disorder · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31645-F1 | alphafold | PREDICTED | 84.69 | — |
Amino-acid sequence (630 residues)
METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT PGTFKERIIK SITPETPTEI PCGDIRLNAV
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