Dexmethylphenidate

Central Nervous System Stimulant — NERVOUS SYSTEM

Key facts

Dexmethylphenidate is an ofp drug in the Central Nervous System Stimulant class catalogued in DrugCentral. It was first approved by the FDA in 2001. DrugCentral lists 5 molecular targets, including SLC6A3, Slc6a3 and Drd1|Drd3|Drd5|Drd4|Drd2. Recorded indications include Attention deficit hyperactivity disorder.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Central Nervous System Stimulant.
• Molecular targets: SLC6A3, Slc6a3, Drd1|Drd3|Drd5|Drd4|Drd2 and Slc6a2 (5 listed in DrugCentral).
• Indications: Attention deficit hyperactivity disorder.
• ATC code: N06BA11 (Centrally acting sympathomimetics).
• Molecular formula: C14H19NO2; molecular weight 233.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Attention deficit hyperactivity disorder

Contraindications (26)

• Aggressive behavior
• Alcoholism
• Anemia
• Bipolar disorder
• Cardiomyopathy
• Cerebrovascular accident
• Chronic heart failure
• Dependent drug abuse
• Disorder of coronary artery
• Feeling agitated
• Gilles de la Tourette's syndrome
• Glaucoma
• Hypertensive disorder
• Leukopenia
• Life-Threatening Cardiac Arrhythmias
• Mania
• Motor tic disorder
• Myocardial infarction
• Psychotic disorder
• Seizure disorder
• Severe anxiety (panic)
• Sinus tachycardia
• Structural disorder of heart
• Tension
• Thrombocytopenic disorder
• Visual impairment

Mechanism & targets

• Established pharmacologic class: Central Nervous System Stimulant

Molecular targets (5)

Target	Gene	Action	Activity
Sodium-dependent dopamine transporter	SLC6A3	inhibitor	Ki 7.80
Sodium-dependent dopamine transporter	Slc6a3	unknown	Ki 7.13
Dopamine receptor	Drd1|Drd3|Drd5|Drd4|Drd2	unknown	IC50 7.08
Transporter	Slc6a2	unknown	Ki 6.57
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-11-13	FDA	—	NOVARTIS

ATC classification

ATC code	Therapeutic hierarchy
N06BA11	NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Centrally acting sympathomimetics
N06BA15	NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Centrally acting sympathomimetics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Product substitution issue	285.7
Abnormal behaviour	229.2
Disturbance in attention	136.5
Aggression	117.7
Drug ineffective	116.8
Suicidal ideation	114.8
Anger	103.6
Irritability	96.8
Tic	94.1
Mood swings	93.4
Product tampering	89.9
Claustrophobia	89.3

Chemical structure

• Molecular formula: C₁₄H₁₉NO₂
• Molecular weight: 233.31 g/mol
• CAS number: —
• InChIKey: DUGOZIWVEXMGBE-CHWSQXEVSA-N
• PubChem CID: 154101

COC(=O)[C@@H]([C@H]1CCCCN1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dexmethylphenidate used for?

DrugCentral lists the following indications for Dexmethylphenidate: Attention deficit hyperactivity disorder.

How does Dexmethylphenidate work?

Its molecular targets in DrugCentral include SLC6A3 (inhibitor), Slc6a3, Drd1|Drd3|Drd5|Drd4|Drd2 and Slc6a2.

When was Dexmethylphenidate first approved?

Dexmethylphenidate was first approved by the FDA in 2001.

What drug class does Dexmethylphenidate belong to?

Dexmethylphenidate is in the Central Nervous System Stimulant class.

What is the chemical formula of Dexmethylphenidate?

Dexmethylphenidate has the molecular formula C14H19NO2 and a molecular weight of 233.31 g/mol.

Sources

• DrugCentral drug card 836 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL827 — compound record and bioactivity
• PubChem CID 154101 — chemical identifiers
• DrugBank DB06701 — drug record
• FDA UNII M32RH9MFGP — substance identity
• DailyMed: FDA labels for Dexmethylphenidate — current prescribing information (label search)
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P23975 (SLC6A2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.