About Sodium-dependent dopamine transporter
Sodium-dependent dopamine transporter (SLC6A3) is a protein
from Homo sapiens identified by UniProt accession
Q01959, 620 residues long.
MolForge cross-references it against 0 known binders and
634 disease associations.
Target properties
| Protein name | Sodium-dependent dopamine transporter |
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| UniProt accession | Q01959 |
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| Gene | SLC6A3 |
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| Organism | Homo sapiens |
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| Length | 620 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (634)
Diseases linked to this target (Open Targets).
- parkinsonism-dystonia, infantile · score 0.72
- nicotine dependence · score 0.71
- classic dopamine transporter deficiency syndrome · score 0.69
- Infantile dystonia-parkinsonism · score 0.68
- attention deficit hyperactivity disorder · score 0.65
- major depressive disorder · score 0.62
- schizophrenia · score 0.62
- unipolar depression · score 0.62
- depressive disorder · score 0.60
- obesity · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01959-F1 | alphafold | PREDICTED | 86.95 | — |
Amino-acid sequence (620 residues)
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD RELVDRGEVR QFTLRHWLKV
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