Phenothiazine

Drug profile

Key facts

Phenothiazine is a drug catalogued in DrugCentral. DrugCentral lists 16 molecular targets, including Sigmar1, CYP1A2 and PTGS1.

• Molecular targets: Sigmar1, CYP1A2, PTGS1 and SLC6A2 (16 listed in DrugCentral).
• Molecular formula: C12H9NS; molecular weight 199.27 g/mol.

Mechanism & targets

Molecular targets (16)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	Sigmar1	unknown	Ki 8.37
Cytochrome P450 1A2	CYP1A2	unknown	IC50 7.80
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 6.71
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	IC50 6.34
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 6.27
Amine oxidase [flavin-containing] A	MAOA	unknown	IC50 6.23
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 5.93
Arachidonate 5-lipoxygenase	Alox5	unknown	IC50 5.85
Sigma intracellular receptor 2	Tmem97	unknown	Ki 5.83
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 5.33
Cholinesterase	BCHE	unknown	IC50 5.24
Acetylcholinesterase	ACHE	unknown	IC50 5.14
Adenosine receptor A3	ADORA3	unknown	Ki 4.84
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 4.83
Cannabinoid receptor 1	CNR1	unknown	Ki 4.71
Alpha-synuclein	SNCA	unknown	IC50 4.58

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Completed suicide	147.9
Toxicity to various agents	68.9
Cardio-respiratory arrest	57.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Phenothiazine is on its molecule page.

• Molecular formula: C₁₂H₉NS
• Molecular weight: 199.27 g/mol
• CAS number: 92-84-2
• InChIKey: WJFKNYWRSNBZNX-UHFFFAOYSA-N
• PubChem CID: 7108

N1C2=CC=CC=C2SC3=C1C=CC=C3

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Phenothiazine work?

Its molecular targets in DrugCentral include Sigmar1, CYP1A2, PTGS1 and SLC6A2.

What is the chemical formula of Phenothiazine?

Phenothiazine has the molecular formula C12H9NS and a molecular weight of 199.27 g/mol.

Sources

• DrugCentral drug card 5597 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL828 — compound record and bioactivity
• PubChem CID 7108 — chemical identifiers
• DrugBank DB11447 — drug record
• FDA UNII GS9EX7QNU6 — substance identity
• DailyMed: FDA labels for Phenothiazine — current prescribing information (label search)
• UniProt P05177 (CYP1A2) — target protein
• UniProt P23219 (PTGS1) — target protein
• UniProt P23975 (SLC6A2) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P21397 (MAOA) — target protein
• UniProt P28335 (HTR2C) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.