5-hydroxytryptamine receptor 2C (HTR2C)

About 5-hydroxytryptamine receptor 2C

5-hydroxytryptamine receptor 2C (HTR2C) is a protein from Homo sapiens identified by UniProt accession P28335, 458 residues long. MolForge cross-references it against 0 known binders and 289 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 2C
UniProt accession	P28335
Gene	HTR2C
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (289)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.61
bipolar disorder · score 0.61
unipolar depression · score 0.61
autism · score 0.61
schizoaffective disorder · score 0.60
major depressive disorder · score 0.60
depressive disorder · score 0.60
bipolar I disorder · score 0.60
aggressive behavior · score 0.60
Agitation · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28335-F1	alphafold	PREDICTED	73.56	—

Amino-acid sequence (458 residues)

MVNLRNAVHS FLVHLIGLLV WQSDISVSPV AAIVTDIFNT SDGGRFKFPD GVQNWPALSI VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRYVAIRNPI EHSRFNSRTK AIMKIAIVWA ISIGVSVPIP VIGLRDEEKV FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIYV LRRQALMLLH GHTEEPPGLS LDFLKCCKRN TAEEENSANP NQDQNARRRK KKERRPRGTM QAINNERKAS KVLGIVFFVF LIMWCPFFIT NILSVLCEKS CNQKLMEKLL NVFVWIGYVC SGINPLVYTL FNKIYRRAFS NYLRCNYKVE KKPPVRQIPR VAATALSGRE LNVNIYRHTN EPVIEKASDN EPGIEMQVEN LELPVNPSSV VSERISSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards