Pindolol

beta-Adrenergic Blocker — CARDIOVASCULAR SYSTEM

Key facts

Pindolol is an ofp drug in the beta-Adrenergic Blocker class catalogued in DrugCentral. It was first approved by the FDA in 1982. Its mechanism of action is classified as Adrenergic beta-Antagonists. DrugCentral lists 17 molecular targets, including ADRB1, ADRB2 and HTR1A. Recorded indications include Hypertensive disorder.

• Approval status: ofp (first approved 1982 by the FDA).
• Drug class: beta-Adrenergic Blocker.
• Mechanism of action: Adrenergic beta-Antagonists.
• Molecular targets: ADRB1, ADRB2, HTR1A and Htr1a (17 listed in DrugCentral).
• Indications: Hypertensive disorder.
• ATC code: C07AA03 (Beta blocking agents, non-selective).
• Molecular formula: C14H20N2O2; molecular weight 248.33 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypertensive disorder

Off-label uses (1)

• Angina pectoris

Contraindications (17)

• Anaphylaxis
• Bronchospasm
• Cardiogenic shock
• Complete atrioventricular block
• Decompensated cardiac failure
• Depressive disorder
• Diabetes mellitus
• Disease of liver
• Kidney disease
• Myasthenia gravis
• Partial atrioventricular block
• Pregnancy, function
• Pulmonary emphysema
• Raynaud's phenomenon
• Right ventricular failure
• Severe chronic obstructive pulmonary disease
• Sinus bradycardia

Mechanism & targets

• Mechanism of action (MoA): Adrenergic beta-Antagonists
• Established pharmacologic class: beta-Adrenergic Blocker

Molecular targets (17)

Target	Gene	Action	Activity
Beta-1 adrenergic receptor	ADRB1	partial agonist	Ki 9.40
Beta-2 adrenergic receptor	ADRB2	partial agonist	Ki 9.00
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 8.10
5-hydroxytryptamine receptor 1A	Htr1a	unknown	Ki 7.70
5-hydroxytryptamine receptor 1B	HTR1B	unknown	Ki 7.10
5-hydroxytryptamine receptor 1B	Htr1b	unknown	Ki 7.10
Serotonin 1 (5-HT1) receptor	Htr1a|Htr1b|Htr1d|Htr1f	unknown	Ki 7.00
Beta-3 adrenergic receptor	ADRB3	unknown	Kd 6.78
D(3) dopamine receptor	DRD3	unknown	Ki 6.00
D(4) dopamine receptor	DRD4	unknown	Ki 5.78
5-hydroxytryptamine receptor 2B	HTR2B	agonist	Ki 5.70
Transmembrane protein 97	TMEM97	unknown	Ki 5.48
5-hydroxytryptamine receptor 1D	HTR1D	unknown	Ki 5.21
5-hydroxytryptamine receptor 5A	HTR5A	unknown	Ki 5.15
5-hydroxytryptamine receptor 2A	HTR2A	agonist	Ki 5.00
Serotonin 2 (5-HT2) receptor	Htr2c|Htr2a|Htr2b	unknown	Ki 4.53
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 4.27

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1982-09-03	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C07AA03	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, non-selective
C07CA03	CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS AND OTHER DIURETICS › Beta blocking agents, non-selective, and other diuretics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Atrioventricular block complete	133.7
Oesophagitis	57.1
White blood cell count abnormal	55.1
Urinary tract infection	52.3
Neutrophil count abnormal	51.2
Haemoglobin abnormal	44.5
Rhabdomyolysis	42.0
Hypertension	40.6
Chromaturia	36.2
Drug interaction	30.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pindolol is on its molecule page.

• Molecular formula: C₁₄H₂₀N₂O₂
• Molecular weight: 248.33 g/mol
• CAS number: 13523-86-9
• InChIKey: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• PubChem CID: 4828

CC(C)NCC(O)COC1=CC=CC2=C1C=CN2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pindolol used for?

DrugCentral lists the following indications for Pindolol: Hypertensive disorder.

How does Pindolol work?

Pindolol is classified as Adrenergic beta-Antagonists; its molecular targets in DrugCentral include ADRB1 (partial agonist), ADRB2 (partial agonist), HTR1A and Htr1a.

When was Pindolol first approved?

Pindolol was first approved by the FDA in 1982.

What drug class does Pindolol belong to?

Pindolol is in the beta-Adrenergic Blocker class.

What is the chemical formula of Pindolol?

Pindolol has the molecular formula C14H20N2O2 and a molecular weight of 248.33 g/mol.

Sources

• DrugCentral drug card 2176 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL500 — compound record and bioactivity
• PubChem CID 4828 — chemical identifiers
• DrugBank DB00960 — drug record
• FDA UNII BJ4HF6IU1D — substance identity
• DailyMed: FDA labels for Pindolol — current prescribing information (label search)
• UniProt P08588 (ADRB1) — target protein
• UniProt P07550 (ADRB2) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P28222 (HTR1B) — target protein
• UniProt P13945 (ADRB3) — target protein
• UniProt P35462 (DRD3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.