Sigma intracellular receptor 2 (TMEM97)

About Sigma intracellular receptor 2

Sigma intracellular receptor 2 (TMEM97) is a protein from Homo sapiens identified by UniProt accession Q5BJF2, 176 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.

Target properties

Protein name	Sigma intracellular receptor 2
UniProt accession	Q5BJF2
Gene	TMEM97
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (204)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.19
sporadic amyotrophic lateral sclerosis · score 0.16
serine/threonine-protein kinase 17B measurement · score 0.16
OCIA domain-containing protein 1 measurement · score 0.16
macrophage scavenger receptor types I and II measurement · score 0.16
Abelson tyrosine-protein kinase 2 measurement · score 0.16
breast cancer anti-estrogen resistance protein 3 measurement · score 0.16
non-receptor tyrosine-protein kinase TYK2 measurement · score 0.16
apolipoprotein A 1 measurement · score 0.15
high density lipoprotein cholesterol measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5BJF2-F1	alphafold	PREDICTED	90.17	—

Amino-acid sequence (176 residues)

MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY AKEFKDPLLQ EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA IIYSVHTMTT LIPILSTFLF EDFSKASGFK GQRPETLHER LTLVSVYAPY LLIPFILLIF MLRSPYYKYE EKRKKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards