Frovatriptan

Serotonin-1b and Serotonin-1d Receptor Agonist — NERVOUS SYSTEM

Key facts

Frovatriptan is an ofp drug in the Serotonin-1b and Serotonin-1d Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2001. Its mechanism of action is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists. DrugCentral lists 9 molecular targets, including HTR1D, HTR1B and HTR7. Recorded indications include Migraine.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Serotonin-1b and Serotonin-1d Receptor Agonist.
• Mechanism of action: Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists.
• Molecular targets: HTR1D, HTR1B, HTR7 and HTR1A (9 listed in DrugCentral).
• Indications: Migraine.
• ATC code: N02CC07 (Selective serotonin (5HT1) agonists).
• Molecular formula: C14H17N3O; molecular weight 243.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Migraine

Contraindications (19)

• Angina pectoris
• Cardiovascular event risk
• Cerebrovascular accident
• Conduction disorder of the heart
• Coronary artery spasm
• Diabetes mellitus
• Disorder of coronary artery
• Hemiplegic migraine
• Hypercholesterolemia
• Hypertensive disorder
• Hypertensive urgency
• Myocardial ischemia
• Obesity
• Peripheral vascular disease
• Prinzmetal angina
• Raynaud's phenomenon
• Serotonin syndrome
• Transient ischemic attack
• Vascular insufficiency of intestine

Mechanism & targets

• Mechanism of action (MoA): Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists
• Established pharmacologic class: Serotonin-1b and Serotonin-1d Receptor Agonist

Molecular targets (9)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1D	HTR1D	agonist	Ki 8.36
5-hydroxytryptamine receptor 1B	HTR1B	agonist	Ki 7.99
5-hydroxytryptamine receptor 7	HTR7	unknown	Ki 7.44
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 7.21
Mu-type opioid receptor	OPRM1	unknown	Ki 6.73
5-hydroxytryptamine receptor 1E	HTR1E	unknown	Ki 6.51
D(2) dopamine receptor	DRD2	unknown	Ki 6.16
D(4) dopamine receptor	DRD4	unknown	Ki 6.04
Transmembrane protein 97	TMEM97	unknown	Ki 5.49

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-11-08	FDA	—	ENDO PHARMS

ATC classification

ATC code	Therapeutic hierarchy
N02CC07	NERVOUS SYSTEM › ANALGESICS › ANTIMIGRAINE PREPARATIONS › Selective serotonin (5HT1) agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug ineffective for unapproved indication	601.1
Swollen tongue	570.2
Dysphonia	520.4
Angioedema	496.3
Swelling face	494.8
Neovascularisation	285.2
Drug intolerance	251.4
Hypersensitivity	244.5
Headache	236.4
Paradoxical drug reaction	198.4
Anuria	154.9
Migraine	152.6

Chemical structure

• Molecular formula: C₁₄H₁₇N₃O
• Molecular weight: 243.31 g/mol
• CAS number: 158747-02-5
• InChIKey: XPSQPHWEGNHMSK-SECBINFHSA-N
• PubChem CID: 77992

CN[C@@H]1CCC2=C(C1)C1=CC(=CC=C1N2)C(N)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Frovatriptan used for?

DrugCentral lists the following indications for Frovatriptan: Migraine.

How does Frovatriptan work?

Frovatriptan is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists; its molecular targets in DrugCentral include HTR1D (agonist), HTR1B (agonist), HTR7 and HTR1A.

When was Frovatriptan first approved?

Frovatriptan was first approved by the FDA in 2001.

What drug class does Frovatriptan belong to?

Frovatriptan is in the Serotonin-1b and Serotonin-1d Receptor Agonist class.

What is the chemical formula of Frovatriptan?

Frovatriptan has the molecular formula C14H17N3O and a molecular weight of 243.31 g/mol.

Sources

• DrugCentral drug card 1251 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1279 — compound record and bioactivity
• PubChem CID 77992 — chemical identifiers
• DrugBank DB00998 — drug record
• FDA UNII H82Q2D5WA7 — substance identity
• DailyMed: FDA labels for Frovatriptan — current prescribing information (label search)
• UniProt P28221 (HTR1D) — target protein
• UniProt P28222 (HTR1B) — target protein
• UniProt P34969 (HTR7) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P35372 (OPRM1) — target protein
• UniProt P28566 (HTR1E) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.