Eletriptan

Serotonin-1b and Serotonin-1d Receptor Agonist — NERVOUS SYSTEM

Key facts

Eletriptan is an ofp drug in the Serotonin-1b and Serotonin-1d Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2002. Its mechanism of action is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists. DrugCentral lists 5 molecular targets, including HTR1D, HTR1B and HTR1F. Recorded indications include Migraine.

• Approval status: ofp (first approved 2002 by the FDA).
• Drug class: Serotonin-1b and Serotonin-1d Receptor Agonist.
• Mechanism of action: Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists.
• Molecular targets: HTR1D, HTR1B, HTR1F and HTR1A (5 listed in DrugCentral).
• Indications: Migraine.
• ATC code: N02CC06 (Selective serotonin (5HT1) agonists).
• Molecular formula: C22H26N2O2S; molecular weight 382.53 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Migraine

Contraindications (24)

• Angina pectoris
• Cardiovascular event risk
• Cerebral ischemia
• Cerebrovascular accident
• Coronary artery spasm
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Familial History of Cardiovascular Disease
• Hemiplegic migraine
• Hepatic failure
• Hypercholesterolemia
• Hypertensive disorder
• Hypertensive urgency
• Myocardial infarction
• Myocardial ischemia
• Obesity
• Peripheral vascular disease
• Prinzmetal angina
• Raynaud's phenomenon
• Serotonin syndrome
• Smokes tobacco daily
• Transient ischemic attack
• Vascular insufficiency of intestine

Mechanism & targets

• Mechanism of action (MoA): Serotonin 1b Receptor Agonists; Serotonin 1d Receptor Agonists
• Established pharmacologic class: Serotonin-1b and Serotonin-1d Receptor Agonist

Molecular targets (5)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1D	HTR1D	agonist	Kd 9.05
5-hydroxytryptamine receptor 1B	HTR1B	agonist	Kd 8.52
5-hydroxytryptamine receptor 1F	HTR1F	agonist	Ki 8.00
5-hydroxytryptamine receptor 1A	HTR1A	agonist	Ki 7.40
5-hydroxytryptamine receptor 1E	HTR1E	agonist	Ki 7.20

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2002-12-26	FDA	—	PFIZER IRELAND

ATC classification

ATC code	Therapeutic hierarchy
N02CC06	NERVOUS SYSTEM › ANALGESICS › ANTIMIGRAINE PREPARATIONS › Selective serotonin (5HT1) agonists

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• Swissmedic label: CYP2D6 · Informative PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Migraine	268.8
Medication overuse headache	257.3
Headache	119.2
Drug ineffective	107.0
Drug dependence	99.1
Paraesthesia	94.4
Drug abuse	93.3
Rheumatoid factor negative	70.3
Intentional product misuse	69.7
Recalled product administered	68.0
Rubber sensitivity	52.6
Feeling abnormal	49.4

Chemical structure

• Molecular formula: C₂₂H₂₆N₂O₂S
• Molecular weight: 382.53 g/mol
• CAS number: —
• InChIKey: PWVXXGRKLHYWKM-LJQANCHMSA-N
• PubChem CID: 77993

CN1CCC[C@@H]1CC1=CNC2=C1C=C(CCS(=O)(=O)C1=CC=CC=C1)C=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Eletriptan used for?

DrugCentral lists the following indications for Eletriptan: Migraine.

How does Eletriptan work?

Eletriptan is classified as Serotonin 1b Receptor Agonists and Serotonin 1d Receptor Agonists; its molecular targets in DrugCentral include HTR1D (agonist), HTR1B (agonist), HTR1F (agonist) and HTR1A (agonist).

When was Eletriptan first approved?

Eletriptan was first approved by the FDA in 2002.

What drug class does Eletriptan belong to?

Eletriptan is in the Serotonin-1b and Serotonin-1d Receptor Agonist class.

What is the chemical formula of Eletriptan?

Eletriptan has the molecular formula C22H26N2O2S and a molecular weight of 382.53 g/mol.

Sources

• DrugCentral drug card 995 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201003 — compound record and bioactivity
• PubChem CID 77993 — chemical identifiers
• DrugBank DB00216 — drug record
• FDA UNII 22QOO9B8KI — substance identity
• DailyMed: FDA labels for Eletriptan — current prescribing information (label search)
• UniProt P28221 (HTR1D) — target protein
• UniProt P28222 (HTR1B) — target protein
• UniProt P30939 (HTR1F) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P28566 (HTR1E) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.