5-hydroxytryptamine receptor 1D (HTR1D)

About 5-hydroxytryptamine receptor 1D

5-hydroxytryptamine receptor 1D (HTR1D) is a protein from Homo sapiens identified by UniProt accession P28221, 377 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 1D
UniProt accession	P28221
Gene	HTR1D
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (109)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.61
schizophrenia · score 0.59
Headache · score 0.57
migraine with aura · score 0.51
pain · score 0.51
migraine without aura · score 0.51
mental or behavioural disorder · score 0.50
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
obesity · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28221-F1	alphafold	PREDICTED	78.96	—

Amino-acid sequence (377 residues)

MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN EEFRQAFQKI VPFRKAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards