5-hydroxytryptamine receptor 1F (HTR1F)

About 5-hydroxytryptamine receptor 1F

5-hydroxytryptamine receptor 1F (HTR1F) is a protein from Homo sapiens identified by UniProt accession P30939, 366 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 1F
UniProt accession	P30939
Gene	HTR1F
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (76)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.60
schizophrenia · score 0.59
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
migraine with aura · score 0.43
depressive disorder · score 0.43
migraine without aura · score 0.43
pain · score 0.37
mental or behavioural disorder · score 0.37
movement disorder · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30939-F1	alphafold	PREDICTED	83.37	—

Amino-acid sequence (366 residues)

MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK LVRCRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards