Xanomeline

Cholinergic Muscarinic Agonist — NERVOUS SYSTEM

Key facts

Xanomeline is an onp drug in the Cholinergic Muscarinic Agonist class catalogued in DrugCentral. Its mechanism of action is classified as Cholinergic Muscarinic Agonists, Cytochrome P450 3A4 Inhibitors and P-Glycoprotein Inhibitors. DrugCentral lists 22 molecular targets, including Chrm1, HTR1D and Chrm1|Chrm3|Chrm4|Chrm5|Chrm2.

• Approval status: onp.
• Drug class: Cholinergic Muscarinic Agonist.
• Mechanism of action: Cholinergic Muscarinic Agonists; Cytochrome P450 3A4 Inhibitors; P-Glycoprotein Inhibitors.
• Molecular targets: Chrm1, HTR1D, Chrm1|Chrm3|Chrm4|Chrm5|Chrm2 and CHRM3 (22 listed in DrugCentral).
• ATC code: N05AX50 (Other antipsychotics).
• Molecular formula: C14H23N3OS; molecular weight 281.42 g/mol.

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Muscarinic Agonists; Cytochrome P450 3A4 Inhibitors; P-Glycoprotein Inhibitors
• Established pharmacologic class: Cholinergic Muscarinic Agonist

Molecular targets (22)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M1	Chrm1	unknown	IC50 8.70
5-hydroxytryptamine receptor 1D	HTR1D	agonist	Ki 8.20
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	IC50 8.01
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 7.89
Muscarinic acetylcholine receptor M2	Chrm2	unknown	IC50 7.80
5-hydroxytryptamine receptor 2B	HTR2B	antagonist	Ki 7.70
5-hydroxytryptamine receptor 2C	HTR2C	antagonist	Ki 7.40
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 7.38
5-hydroxytryptamine receptor 1B	HTR1B	agonist	Ki 7.30
5-hydroxytryptamine receptor 1A	HTR1A	agonist	Ki 7.20
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 7.14
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 7.10
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 6.92
5-hydroxytryptamine receptor 7	HTR7	agonist	Ki 6.90
5-hydroxytryptamine receptor 2A	HTR2A	antagonist	Ki 6.90
5-hydroxytryptamine receptor 1F	HTR1F	agonist	Ki 6.50
D(3) dopamine receptor	DRD3	unknown	Ki 6.40
D(2) dopamine receptor	DRD2	unknown	Ki 6.00
5-hydroxytryptamine receptor 6	HTR6	agonist	Ki 5.90
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 5.80

ATC classification

ATC code	Therapeutic hierarchy
N05AX50	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Other antipsychotics

Chemical structure

• Molecular formula: C₁₄H₂₃N₃OS
• Molecular weight: 281.42 g/mol
• CAS number: 131986-45-3
• InChIKey: JOLJIIDDOBNFHW-UHFFFAOYSA-N
• PubChem CID: 60809

CCCCCCOC1=NSN=C1C1=CCCN(C)C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Xanomeline work?

Xanomeline is classified as Cholinergic Muscarinic Agonists, Cytochrome P450 3A4 Inhibitors and P-Glycoprotein Inhibitors; its molecular targets in DrugCentral include Chrm1, HTR1D (agonist), Chrm1|Chrm3|Chrm4|Chrm5|Chrm2 and CHRM3.

What drug class does Xanomeline belong to?

Xanomeline is in the Cholinergic Muscarinic Agonist class.

What is the chemical formula of Xanomeline?

Xanomeline has the molecular formula C14H23N3OS and a molecular weight of 281.42 g/mol.

Sources

• DrugCentral drug card 3652 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL21536 — compound record and bioactivity
• PubChem CID 60809 — chemical identifiers
• DrugBank DB15357 — drug record
• FDA UNII 9ORI6L73CJ — substance identity
• UniProt P28221 (HTR1D) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt P28335 (HTR2C) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P28222 (HTR1B) — target protein

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