Trospium

Cholinergic Muscarinic Antagonist — ALIMENTARY TRACT AND METABOLISM

Key facts

Trospium is an ofp drug in the Cholinergic Muscarinic Antagonist class catalogued in DrugCentral. It was first approved by the FDA in 2004. Its mechanism of action is classified as Cholinergic Muscarinic Antagonists. DrugCentral lists 5 molecular targets, including CHRM3, CHRM2 and CHRM4. Recorded indications include Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.

• Approval status: ofp (first approved 2004 by the FDA).
• Drug class: Cholinergic Muscarinic Antagonist.
• Mechanism of action: Cholinergic Muscarinic Antagonists.
• Molecular targets: CHRM3, CHRM2, CHRM4 and CHRM1 (5 listed in DrugCentral).
• Indications: Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.
• ATC code: A03DA06 (Synthetic anticholinergic agents in combination with analgesics).
• Molecular formula: C25H30NO3+; molecular weight 392.52 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Bladder muscle dysfunction - overactive
• Increased Urinary Frequency
• Urge incontinence of urine
• Urgent desire to urinate

Contraindications (12)

• Acute nephropathy
• Angle-closure glaucoma
• Atony of colon
• Bladder outflow obstruction
• Constipation
• Disease of liver
• Gastric retention
• Gastrointestinal hypomotility
• Gastrointestinal obstruction
• Myasthenia gravis
• Retention of urine
• Ulcerative colitis

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Muscarinic Antagonists
• Established pharmacologic class: Cholinergic Muscarinic Antagonist

Molecular targets (5)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	Ki 8.99
Muscarinic acetylcholine receptor M2	CHRM2	antagonist	Ki 8.94
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 8.84
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 8.46
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 8.22

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2004-05-28	FDA	—	ALLERGAN

ATC classification

ATC code	Therapeutic hierarchy
A03DA06	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH ANALGESICS › Synthetic anticholinergic agents in combination with analgesics
G04BD09	GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
N05AX50	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Other antipsychotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Pancreatic steatosis	174.1
Femoral hernia incarcerated	172.3
Lymphatic fistula	171.9
Wound infection pseudomonas	153.4
Arterial haemorrhage	145.8
Fall	145.1
Aortic valve stenosis	137.6
Seroma	131.7
Faecaloma	131.5
Urinary tract infection	128.1
Wound dehiscence	114.3
General physical health deterioration	112.7

Chemical structure

• Molecular formula: C₂₅H₃₀NO₃+
• Molecular weight: 392.52 g/mol
• CAS number: —
• InChIKey: OYYDSUSKLWTMMQ-JKHIJQBDSA-N
• PubChem CID: 5284632

OC(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)(C1=CC=CC=C1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Trospium used for?

DrugCentral lists the following indications for Trospium: Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.

How does Trospium work?

Trospium is classified as Cholinergic Muscarinic Antagonists; its molecular targets in DrugCentral include CHRM3 (antagonist), CHRM2 (antagonist), CHRM4 and CHRM1.

When was Trospium first approved?

Trospium was first approved by the FDA in 2004.

What drug class does Trospium belong to?

Trospium is in the Cholinergic Muscarinic Antagonist class.

What is the chemical formula of Trospium?

Trospium has the molecular formula C25H30NO3+ and a molecular weight of 392.52 g/mol.

Sources

• DrugCentral drug card 2776 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1888176 — compound record and bioactivity
• PubChem CID 5284632 — chemical identifiers
• DrugBank DB00209 — drug record
• FDA UNII T4Y8ORK057 — substance identity
• DailyMed: FDA labels for Trospium — current prescribing information (label search)
• UniProt P20309 (CHRM3) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08912 (CHRM5) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.