About Muscarinic acetylcholine receptor M1
Muscarinic acetylcholine receptor M1 (CHRM1) is a protein
from Homo sapiens identified by UniProt accession
P11229, 460 residues long.
MolForge cross-references it against 0 known binders and
229 disease associations.
Target properties
| Protein name | Muscarinic acetylcholine receptor M1 |
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| UniProt accession | P11229 |
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| Gene | CHRM1 |
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| Organism | Homo sapiens |
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| Length | 460 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (229)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.67
- chronic obstructive pulmonary disease · score 0.60
- Myopia · score 0.60
- gastrointestinal disease · score 0.58
- cycloplegia · score 0.58
- Mydriasis · score 0.57
- Peptic ulcer · score 0.57
- seasonal allergic rhinitis · score 0.57
- Hyperhidrosis · score 0.56
- allergic rhinitis · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11229-F1 | alphafold | PREDICTED | 74.67 | — |
Amino-acid sequence (460 residues)
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC
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