Aceclidine

Cholinergic Receptor Agonist — SENSORY ORGANS

Key facts

Aceclidine is an onp drug in the Cholinergic Receptor Agonist class catalogued in DrugCentral. Its mechanism of action is classified as Cholinergic Muscarinic Agonists. DrugCentral lists 7 molecular targets, including Chrm1, CHRM2 and CHRM3. Recorded indications include Open-angle glaucoma.

• Approval status: onp.
• Drug class: Cholinergic Receptor Agonist.
• Mechanism of action: Cholinergic Muscarinic Agonists.
• Molecular targets: Chrm1, CHRM2, CHRM3 and CHRM5 (7 listed in DrugCentral).
• Indications: Open-angle glaucoma.
• ATC code: S01EB08 (Parasympathomimetics).
• Molecular formula: C9H15NO2; molecular weight 169.22 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Open-angle glaucoma

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Muscarinic Agonists
• Established pharmacologic class: Cholinergic Receptor Agonist

Molecular targets (7)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M1	Chrm1	unknown	IC50 6.92
Muscarinic acetylcholine receptor M2	CHRM2	agonist	EC50 5.70
Muscarinic acetylcholine receptor M3	CHRM3	agonist	EC50 5.10
Muscarinic acetylcholine receptor M5	CHRM5	agonist	EC50 5.10
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	Ki 5.08
Muscarinic acetylcholine receptor M1	CHRM1	agonist	EC50 5.00
Muscarinic acetylcholine receptor M4	CHRM4	agonist	EC50 4.80

ATC classification

ATC code	Therapeutic hierarchy
S01EB08	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics
S01EB58	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Ocular hyperaemia	500.3
Instillation site irritation	499.3
Visual impairment	281.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Aceclidine is on its molecule page.

• Molecular formula: C₉H₁₅NO₂
• Molecular weight: 169.22 g/mol
• CAS number: —
• InChIKey: WRJPSSPFHGNBMG-UHFFFAOYSA-N
• PubChem CID: 1979

CC(=O)OC1CN2CCC1CC2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Aceclidine used for?

DrugCentral lists the following indications for Aceclidine: Open-angle glaucoma.

How does Aceclidine work?

Aceclidine is classified as Cholinergic Muscarinic Agonists; its molecular targets in DrugCentral include Chrm1, CHRM2 (agonist), CHRM3 (agonist) and CHRM5 (agonist).

What drug class does Aceclidine belong to?

Aceclidine is in the Cholinergic Receptor Agonist class.

What is the chemical formula of Aceclidine?

Aceclidine has the molecular formula C9H15NO2 and a molecular weight of 169.22 g/mol.

Sources

• DrugCentral drug card 4314 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL20835 — compound record and bioactivity
• PubChem CID 1979 — chemical identifiers
• DrugBank DB13262 — drug record
• FDA UNII 0578K3ELIO — substance identity
• UniProt P08172 (CHRM2) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08173 (CHRM4) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.