Fluostigmine

SENSORY ORGANS

Key facts

Fluostigmine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1957. DrugCentral lists 6 molecular targets, including Liver carboxylesterase, PTGS2 and ache.

• Approval status: ofm (first approved 1957 by the FDA).
• Molecular targets: Liver carboxylesterase, PTGS2, ache and ACHE (6 listed in DrugCentral).
• ATC code: S01EB07 (Parasympathomimetics).
• Molecular formula: C6H14FO3P; molecular weight 184.15 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Liver carboxylesterase	—	unknown	IC50 7.30
Prostaglandin G/H synthase 2	PTGS2	unknown	Ki 6.77
Acetylcholinesterase	ache	unknown	IC50 6.32
Acetylcholinesterase	ACHE	inhibitor	Ki 5.22
Lysosomal protective protein	CTSA	unknown	IC50 5.00
Acetylcholinesterase	ache	unknown	Kd 4.15

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1957-04-02	FDA	—	MERCK

ATC classification

ATC code	Therapeutic hierarchy
S01EB07	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Fluostigmine is on its molecule page.

• Molecular formula: C₆H₁₄FO₃P
• Molecular weight: 184.15 g/mol
• CAS number: —
• InChIKey: MUCZHBLJLSDCSD-UHFFFAOYSA-N
• PubChem CID: 5936

CC(C)OP(F)(=O)OC(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Fluostigmine work?

Its molecular targets in DrugCentral include Liver carboxylesterase, PTGS2, ache and ACHE (inhibitor).

When was Fluostigmine first approved?

Fluostigmine was first approved by the FDA in 1957.

What is the chemical formula of Fluostigmine?

Fluostigmine has the molecular formula C6H14FO3P and a molecular weight of 184.15 g/mol.

Sources

• DrugCentral drug card 1494 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1025 — compound record and bioactivity
• PubChem CID 5936 — chemical identifiers
• DrugBank DB00677 — drug record
• FDA UNII 12UHW9R67N — substance identity
• DailyMed: FDA labels for Fluostigmine — current prescribing information (label search)
• UniProt P35354 (PTGS2) — target protein
• UniProt P22303 (ACHE) — target protein
• UniProt P10619 (CTSA) — target protein

How this page is built: methodology · editorial policy & corrections.