About Lysosomal protective protein
Lysosomal protective protein (CTSA) is a protein
from Homo sapiens identified by UniProt accession
P10619, 480 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | Lysosomal protective protein |
|---|
| UniProt accession | P10619 |
|---|
| Gene | CTSA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 480 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (221)
Diseases linked to this target (Open Targets).
- galactosialidosis · score 0.85
- genetic disorder · score 0.45
- Lysosomal disease · score 0.37
- Non-immune hydrops fetalis · score 0.27
- Abnormality of prenatal development or birth · score 0.27
- Intellectual disability · score 0.26
- Seizure · score 0.26
- hepatocellular carcinoma · score 0.10
- body height · score 0.08
- lung adenocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10619-F1 | alphafold | PREDICTED | 94.50 | — |
Amino-acid sequence (480 residues)
MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY SGYLKGSGSK HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP FLVQPDGVTL EYNPYSWNLI ANVLYLESPA GVGFSYSDDK FYATNDTEVA QSNFEALQDF FRLFPEYKNN KLFLTGESYA GIYIPTLAVL VMQDPSMNLQ GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC CSQNKCNFYD NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL NIPEQLPQWD MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD MACNFMGDEW FVDSLNQKME VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY
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