Acetylcholine

Cholinergic Receptor Agonist — SENSORY ORGANS

Key facts

Acetylcholine is an ofp drug in the Cholinergic Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 1973. Its mechanism of action is classified as Cholinergic Agonists. DrugCentral lists 17 molecular targets, including Chrna4|Chrnb2, Chrna2|Chrnb2 and Chrm1|Chrm3|Chrm4|Chrm5|Chrm2. Recorded indications include Glaucoma.

• Approval status: ofp (first approved 1973 by the FDA).
• Drug class: Cholinergic Receptor Agonist.
• Mechanism of action: Cholinergic Agonists.
• Molecular targets: Chrna4|Chrnb2, Chrna2|Chrnb2, Chrm1|Chrm3|Chrm4|Chrm5|Chrm2 and Chrna3|Chrnb2 (17 listed in DrugCentral).
• Indications: Glaucoma.
• ATC code: S01EB09 (Parasympathomimetics).
• Molecular formula: C7H16NO2+; molecular weight 146.21 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Glaucoma

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Agonists
• Established pharmacologic class: Cholinergic Receptor Agonist

Molecular targets (17)

Target	Gene	Action	Activity
Neuronal acetylcholine receptor; alpha4/beta2	Chrna4|Chrnb2	unknown	Ki 8.12
Neuronal acetylcholine receptor; alpha2/beta2	Chrna2|Chrnb2	unknown	Ki 7.96
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	IC50 7.92
Neuronal acetylcholine receptor; alpha3/beta2	Chrna3|Chrnb2	unknown	Ki 7.39
Acetylcholine receptor subunit delta	chrnd	unknown	Ki 7.37
Neuronal acetylcholine receptor; alpha4/beta4	Chrna4|Chrnb4	unknown	Ki 7.24
Muscarinic acetylcholine receptor M3	CHRM3	agonist	EC50 6.66
Muscarinic acetylcholine receptor M2	CHRM2	agonist	Ki 6.50
Neuronal acetylcholine receptor; alpha3/beta4	Chrna3|Chrnb4	unknown	Ki 6.21
Muscarinic acetylcholine receptor M1	CHRM1	unknown	EC50 6.11
Muscarinic acetylcholine receptor M5	CHRM5	unknown	EC50 6.10
Neuronal acetylcholine receptor; alpha4/beta2	CHRNB2|CHRNA4	unknown	EC50 5.80
Muscarinic acetylcholine receptor M4	CHRM4	agonist	Ki 5.60
Acetylcholine-binding protein	—	unknown	Ki 5.50
Neuronal acetylcholine receptor subunit alpha-7	Chrna7	unknown	Ki 5.45
Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	unknown	Ki 5.10
Nicotinic acetylcholine receptor alpha8 subunit	—	unknown	EC50 4.94

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1973-10-09	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
S01EB09	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Acetylcholine is on its molecule page.

• Molecular formula: C₇H₁₆NO₂+
• Molecular weight: 146.21 g/mol
• CAS number: —
• InChIKey: OIPILFWXSMYKGL-UHFFFAOYSA-N
• PubChem CID: 187

CC(=O)OCC[N+](C)(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Acetylcholine used for?

DrugCentral lists the following indications for Acetylcholine: Glaucoma.

How does Acetylcholine work?

Acetylcholine is classified as Cholinergic Agonists; its molecular targets in DrugCentral include Chrna4|Chrnb2, Chrna2|Chrnb2, Chrm1|Chrm3|Chrm4|Chrm5|Chrm2 and Chrna3|Chrnb2.

When was Acetylcholine first approved?

Acetylcholine was first approved by the FDA in 1973.

What drug class does Acetylcholine belong to?

Acetylcholine is in the Cholinergic Receptor Agonist class.

What is the chemical formula of Acetylcholine?

Acetylcholine has the molecular formula C7H16NO2+ and a molecular weight of 146.21 g/mol.

Sources

• DrugCentral drug card 65 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1184 — compound record and bioactivity
• PubChem CID 187 — chemical identifiers
• DrugBank DB03128 — drug record
• FDA UNII N9YNS0M02X — substance identity
• DailyMed: FDA labels for Acetylcholine — current prescribing information (label search)
• UniProt P20309 (CHRM3) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P36544 (CHRNA7) — target protein

How this page is built: methodology · editorial policy & corrections.