About Neuronal acetylcholine receptor subunit alpha-7
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) is a protein
from Homo sapiens identified by UniProt accession
P36544, 502 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-7 |
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| UniProt accession | P36544 |
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| Gene | CHRNA7 |
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| Organism | Homo sapiens |
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| Length | 502 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (211)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.41
- neurodegenerative disease · score 0.35
- Dementia · score 0.32
- Parkinson disease · score 0.21
- lysosomal storage disease · score 0.21
- multiple sclerosis · score 0.21
- lung adenocarcinoma · score 0.15
- schizophrenia · score 0.13
- 15q11q13 microduplication syndrome · score 0.12
- chromosome 15q13.3 microdeletion syndrome · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36544-F1 | alphafold | PREDICTED | 78.33 | — |
Amino-acid sequence (502 residues)
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD FA
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