Carbachol

NERVOUS SYSTEM

Key facts

Carbachol is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1972. DrugCentral lists 22 molecular targets, including Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, CHRM3 and CHRM1. Recorded indications include Open-angle glaucoma.

• Approval status: ofp (first approved 1972 by the FDA).
• Molecular targets: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, CHRM3, CHRM1 and Chrm2 (22 listed in DrugCentral).
• Indications: Open-angle glaucoma.
• ATC code: N07AB01 (Choline esters).
• Molecular formula: C6H15N2O2+; molecular weight 147.20 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Open-angle glaucoma

Off-label uses (2)

• Angle-closure glaucoma
• Secondary glaucoma

Contraindications (9)

• Abdominal pain
• Asthma
• Bradycardia
• Heart failure
• Hyperthyroidism
• Low blood pressure
• Parkinsonism
• Peptic ulcer
• Urinary tract obstruction

Mechanism & targets

Molecular targets (22)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	Ki 8.89
Muscarinic acetylcholine receptor M3	CHRM3	agonist	EC50 8.70
Muscarinic acetylcholine receptor M1	CHRM1	unknown	EC50 8.52
Muscarinic acetylcholine receptor M2	Chrm2	unknown	Ki 8.40
Acetylcholinesterase	Ache	unknown	Ki 8.10
Muscarinic acetylcholine receptor M2	Chrm2	unknown	Ki 8.10
Muscarinic acetylcholine receptor M5	CHRM5	unknown	EC50 8.10
Muscarinic acetylcholine receptor M2	CHRM2	unknown	EC50 7.92
Muscarinic acetylcholine receptor M1	Chrm1	unknown	Ki 7.70
Muscarinic acetylcholine receptor M4	CHRM4	unknown	EC50 7.58
Muscarinic acetylcholine receptor M1	Chrm1	unknown	Ki 7.51
Neuronal acetylcholine receptor; alpha2/beta2	Chrna2|Chrnb2	unknown	Ki 6.68
Acetylcholine receptor subunit delta	chrnd	unknown	Ki 6.35
Neuronal acetylcholine receptor; alpha4/beta2	Chrna4|Chrnb2	unknown	Ki 6.23
Neuronal acetylcholine receptor; alpha4/beta2	CHRNB2|CHRNA4	unknown	Ki 6.12
Neuronal acetylcholine receptor; alpha3/beta2	Chrna3|Chrnb2	unknown	Ki 5.96
Neuronal acetylcholine receptor; alpha4/beta4	Chrna4|Chrnb4	unknown	Ki 5.89
Muscarinic acetylcholine receptor M4	Chrm4	unknown	Ki 5.59
Neuronal acetylcholine receptor; alpha3/beta4	Chrna3|Chrnb4	unknown	Ki 5.32
Acetylcholine receptor subunit alpha	CHRNA1	unknown	IC50 5.12

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1972-09-28	FDA	—	ALCON

ATC classification

ATC code	Therapeutic hierarchy
N07AB01	NERVOUS SYSTEM › OTHER NERVOUS SYSTEM DRUGS › PARASYMPATHOMIMETICS › Choline esters
S01EB02	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics

Chemical structure

• Molecular formula: C₆H₁₅N₂O₂+
• Molecular weight: 147.20 g/mol
• CAS number: —
• InChIKey: VPJXQGSRWJZDOB-UHFFFAOYSA-O
• PubChem CID: 5831

C[N+](C)(C)CCOC(N)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Carbachol used for?

DrugCentral lists the following indications for Carbachol: Open-angle glaucoma.

How does Carbachol work?

Its molecular targets in DrugCentral include Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, CHRM3 (agonist), CHRM1 and Chrm2.

When was Carbachol first approved?

Carbachol was first approved by the FDA in 1972.

What is the chemical formula of Carbachol?

Carbachol has the molecular formula C6H15N2O2+ and a molecular weight of 147.20 g/mol.

Sources

• DrugCentral drug card 488 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL14 — compound record and bioactivity
• PubChem CID 5831 — chemical identifiers
• DrugBank DB00411 — drug record
• FDA UNII 8Y164V895Y — substance identity
• DailyMed: FDA labels for Carbachol — current prescribing information (label search)
• UniProt P20309 (CHRM3) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P36544 (CHRNA7) — target protein

How this page is built: methodology · editorial policy & corrections.