About Muscarinic acetylcholine receptor M5
Muscarinic acetylcholine receptor M5 (CHRM5) is a protein
from Homo sapiens identified by UniProt accession
P08912, 532 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Muscarinic acetylcholine receptor M5 |
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| UniProt accession | P08912 |
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| Gene | CHRM5 |
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| Organism | Homo sapiens |
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| Length | 532 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (77)
Diseases linked to this target (Open Targets).
- chronic obstructive pulmonary disease · score 0.60
- Hyperhidrosis · score 0.56
- peptic ulcer disease · score 0.55
- asthma · score 0.53
- cardiac arrhythmia · score 0.53
- chronic bronchitis · score 0.50
- cerebral palsy · score 0.46
- post operative nausea and vomiting · score 0.46
- Drooling · score 0.38
- gallstones · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08912-F1 | alphafold | PREDICTED | 68.60 | — |
Amino-acid sequence (532 residues)
MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP
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