Bromperidol

NERVOUS SYSTEM

Key facts

Bromperidol is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1973. DrugCentral lists 12 molecular targets, including SIGMAR1, DRD2 and DRD4.

• Molecular targets: SIGMAR1, DRD2, DRD4 and DRD3 (12 listed in DrugCentral).
• ATC code: N05AD06 (Butyrophenone derivatives).
• Molecular formula: C21H23BrFNO2; molecular weight 420.32 g/mol.

Mechanism & targets

Molecular targets (12)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	EC50 9.02
D(2) dopamine receptor	DRD2	antagonist	Ki 8.43
D(4) dopamine receptor	DRD4	unknown	Ki 7.80
D(3) dopamine receptor	DRD3	unknown	Ki 7.50
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 7.10
D(1A) dopamine receptor	DRD1	unknown	Ki 7.00
Histamine H1 receptor	HRH1	unknown	Ki 6.16
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 5.77
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 5.75
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 5.32
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 5.15
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 5.12

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1973-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05AD06	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Bromperidol is on its molecule page.

• Molecular formula: C₂₁H₂₃BrFNO₂
• Molecular weight: 420.32 g/mol
• CAS number: 10457-90-6
• InChIKey: RKLNONIVDFXQRX-UHFFFAOYSA-N
• PubChem CID: 2448

OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Br)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Bromperidol work?

Its molecular targets in DrugCentral include SIGMAR1, DRD2 (antagonist), DRD4 and DRD3.

When was Bromperidol first approved?

Bromperidol was first approved by the YEAR INTRODUCED in 1973.

What is the chemical formula of Bromperidol?

Bromperidol has the molecular formula C21H23BrFNO2 and a molecular weight of 420.32 g/mol.

Sources

• DrugCentral drug card 407 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL28218 — compound record and bioactivity
• PubChem CID 2448 — chemical identifiers
• DrugBank DB12401 — drug record
• FDA UNII LYH6F7I22E — substance identity
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P21917 (DRD4) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P35348 (ADRA1A) — target protein
• UniProt P21728 (DRD1) — target protein

How this page is built: methodology · editorial policy & corrections.