D(1A) dopamine receptor (DRD1)

About D(1A) dopamine receptor

D(1A) dopamine receptor (DRD1) is a protein from Homo sapiens identified by UniProt accession P21728, 446 residues long. MolForge cross-references it against 0 known binders and 303 disease associations.

Target properties

Protein name	D(1A) dopamine receptor
UniProt accession	P21728
Gene	DRD1
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (303)

Diseases linked to this target (Open Targets).

hemorrhage · score 0.60
Parkinson disease · score 0.59
cardiovascular disease · score 0.54
unipolar depression · score 0.54
schizophrenia · score 0.51
Tourette syndrome · score 0.48
hypertension · score 0.47
neurodegenerative disease · score 0.46
coronary artery disease · score 0.46
kidney failure · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21728-F1	alphafold	PREDICTED	72.46	—

Amino-acid sequence (446 residues)

MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards