Norepinephrine

Catecholamine — CARDIOVASCULAR SYSTEM

Key facts

Norepinephrine is an ofp drug in the Catecholamine class catalogued in DrugCentral. It was first approved by the FDA in 1950. DrugCentral lists 27 molecular targets, including Adra2b|Adra2c|Adra2a, Adra1b|Adra2b|Adra2c|Adra2a|Adra1d|Adra1a and ADRA1D. Recorded indications include Acute exacerbation of asthma, Asthma, Asthma management and Bronchiectasis.

• Approval status: ofp (first approved 1950 by the FDA).
• Drug class: Catecholamine.
• Molecular targets: Adra2b|Adra2c|Adra2a, Adra1b|Adra2b|Adra2c|Adra2a|Adra1d|Adra1a, ADRA1D and ADRA2C (27 listed in DrugCentral).
• Indications: Acute exacerbation of asthma, Asthma, Asthma management, Bronchiectasis and Bronchitis and others.
• ATC code: C01CA03 (Adrenergic and dopaminergic agents).
• Molecular formula: C8H11NO3; molecular weight 169.18 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (7)

• Acute exacerbation of asthma
• Asthma
• Asthma management
• Bronchiectasis
• Bronchitis
• Low blood pressure
• Pulmonary emphysema

Contraindications (6)

• Hypercapnia
• Hypertensive disorder
• Hypovolemia
• Hypoxia
• Occlusive Vascular Disease
• Thrombosis

Mechanism & targets

• Established pharmacologic class: Catecholamine

Molecular targets (27)

Target	Gene	Action	Activity
Adrenergic receptor alpha-2	Adra2b|Adra2c|Adra2a	unknown	Ki 8.32
Adrenergic receptor alpha	Adra1b|Adra2b|Adra2c|Adra2a|Adra1d|Adra1a	unknown	IC50 7.80
Alpha-1D adrenergic receptor	ADRA1D	agonist	Ki 7.40
Alpha-2C adrenergic receptor	ADRA2C	agonist	Ki 7.20
Alpha-2A adrenergic receptor	ADRA2A	agonist	Ki 7.18
Alpha-2B adrenergic receptor	Adra2b	unknown	Ki 7.11
Beta-1 adrenergic receptor	Adrb1	unknown	Ki 6.90
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 6.58
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.48
Adrenergic receptor alpha-1	Adra1b|Adra1d|Adra1a	unknown	Ki 6.41
Beta-1 adrenergic receptor	ADRB1	unknown	Ki 6.40
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 6.35
Alpha-2C adrenergic receptor	Adra2c	unknown	Ki 6.19
Adrenergic receptor beta	Adrb2|Adrb1|Adrb3	unknown	IC50 6.00
Beta-1 adrenergic receptor	ADRB1	agonist	Ki 6.00
D(2) dopamine receptor	DRD2	unknown	Ki 5.89
Alpha-1A adrenergic receptor	ADRA1A	agonist	Ki 5.82
Beta-2 adrenergic receptor	ADRB2	agonist	Kd 5.40
Beta-2 adrenergic receptor	Adrb2	unknown	Ki 5.38
Beta-3 adrenergic receptor	ADRB3	unknown	Ki 5.37

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1950-07-13	FDA	—	HOSPIRA

ATC classification

ATC code	Therapeutic hierarchy
C01CA03	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Multiple organ dysfunction syndrome	1518.3
Drug ineffective	1165.6
Cardiogenic shock	1009.1
Appendicolith	659.3
Cardiac arrest	634.0
Septic shock	622.8
Shock	528.0
Ventricular fibrillation	511.0
Appendicitis	500.0
Hypotension	490.5
Acute kidney injury	471.7
Metabolic acidosis	455.8

Chemical structure

• Molecular formula: C₈H₁₁NO₃
• Molecular weight: 169.18 g/mol
• CAS number: —
• InChIKey: SFLSHLFXELFNJZ-QMMMGPOBSA-N
• PubChem CID: 439260

NC[C@H](O)C1=CC(O)=C(O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Norepinephrine used for?

DrugCentral lists the following indications for Norepinephrine: Acute exacerbation of asthma, Asthma, Asthma management, Bronchiectasis, Bronchitis, Low blood pressure and Pulmonary emphysema.

How does Norepinephrine work?

Its molecular targets in DrugCentral include Adra2b|Adra2c|Adra2a, Adra1b|Adra2b|Adra2c|Adra2a|Adra1d|Adra1a, ADRA1D (agonist) and ADRA2C (agonist).

When was Norepinephrine first approved?

Norepinephrine was first approved by the FDA in 1950.

What drug class does Norepinephrine belong to?

Norepinephrine is in the Catecholamine class.

What is the chemical formula of Norepinephrine?

Norepinephrine has the molecular formula C8H11NO3 and a molecular weight of 169.18 g/mol.

Sources

• DrugCentral drug card 1960 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1434513 — compound record and bioactivity
• PubChem CID 439260 — chemical identifiers
• DrugBank DB00368 — drug record
• FDA UNII IFY5PE3ZRW — substance identity
• DailyMed: FDA labels for Norepinephrine — current prescribing information (label search)
• UniProt P25100 (ADRA1D) — target protein
• UniProt P18825 (ADRA2C) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P08588 (ADRB1) — target protein
• UniProt P14416 (DRD2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.