About Alpha-1D adrenergic receptor
Alpha-1D adrenergic receptor (ADRA1D) is a protein
from Homo sapiens identified by UniProt accession
P25100, 572 residues long.
MolForge cross-references it against 0 known binders and
642 disease associations.
Target properties
| Protein name | Alpha-1D adrenergic receptor |
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| UniProt accession | P25100 |
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| Gene | ADRA1D |
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| Organism | Homo sapiens |
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| Length | 572 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (642)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.63
- hypertension · score 0.63
- benign prostatic hyperplasia · score 0.62
- Nasal congestion · score 0.61
- common cold · score 0.61
- myocardial infarction · score 0.61
- seasonal allergic rhinitis · score 0.61
- hypotension · score 0.60
- pain · score 0.60
- sinusitis · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25100-F1 | alphafold | PREDICTED | 64.79 | — |
Amino-acid sequence (572 residues)
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV AEGATCQAYE LADYSNLRET DI
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