Methoxamine
CARDIOVASCULAR SYSTEM
Also known as: methoxamin, methoxamine HCl, methoxamine hydrochloride
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Methoxamine is an ofm drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including Adra2b|Adra2c|Adra2a, ADRA1A and ADRA1D. Recorded indications include Low blood pressure and Paroxysmal supraventricular tachycardia.
- Approval status: ofm.
- Molecular targets: Adra2b|Adra2c|Adra2a, ADRA1A, ADRA1D and Adra1d (5 listed in DrugCentral).
- Indications: Low blood pressure and Paroxysmal supraventricular tachycardia.
- ATC code: C01CA10 (Adrenergic and dopaminergic agents).
- Molecular formula: C11H17NO3; molecular weight 211.26 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (2)
- Low blood pressure
- Paroxysmal supraventricular tachycardia
Mechanism & targets
Molecular targets (5)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Adrenergic receptor alpha-2 | Adra2b|Adra2c|Adra2a | unknown | IC50 5.44 |
| Alpha-1A adrenergic receptor | ADRA1A | agonist | EC50 5.10 |
| Alpha-1D adrenergic receptor | ADRA1D | agonist | EC50 4.90 |
| Alpha-1D adrenergic receptor | Adra1d | agonist | Ki 4.50 |
| Alpha-1B adrenergic receptor | ADRA1B | agonist | Ki 4.00 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| — | FDA | — | GLAXOSMITHKLINE |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C01CA10 | CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Adrenergic and dopaminergic agents |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Methoxamine is on its molecule page.
| Molecular formula | C11H17NO3 |
|---|---|
| Molecular weight | 211.26 g/mol |
| CAS number | — |
| InChIKey | WJAJPNHVVFWKKL-UHFFFAOYSA-N |
| PubChem CID | 6082 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Methoxamine used for?
DrugCentral lists the following indications for Methoxamine: Low blood pressure and Paroxysmal supraventricular tachycardia.
How does Methoxamine work?
Its molecular targets in DrugCentral include Adra2b|Adra2c|Adra2a, ADRA1A (agonist), ADRA1D (agonist) and Adra1d (agonist).
What is the chemical formula of Methoxamine?
Methoxamine has the molecular formula C11H17NO3 and a molecular weight of 211.26 g/mol.
Browse: all drugs starting with M · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 1753 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1201103 — compound record and bioactivity
- PubChem CID 6082 — chemical identifiers
- DrugBank DB00723 — drug record
- FDA UNII HUQ1KC1YLI — substance identity
- DailyMed: FDA labels for Methoxamine — current prescribing information (label search)
- UniProt P35348 (ADRA1A) — target protein
- UniProt P25100 (ADRA1D) — target protein
- UniProt P35368 (ADRA1B) — target protein
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