Alpha-1B adrenergic receptor (ADRA1B)

About Alpha-1B adrenergic receptor

Alpha-1B adrenergic receptor (ADRA1B) is a protein from Homo sapiens identified by UniProt accession P35368, 520 residues long. MolForge cross-references it against 0 known binders and 562 disease associations.

Target properties

Protein name	Alpha-1B adrenergic receptor
UniProt accession	P35368
Gene	ADRA1B
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (562)

Diseases linked to this target (Open Targets).

hypertension · score 0.62
benign prostatic hyperplasia · score 0.61
Nasal congestion · score 0.61
common cold · score 0.61
seasonal allergic rhinitis · score 0.61
myocardial infarction · score 0.61
hypotension · score 0.60
pain · score 0.60
sinusitis · score 0.60
hemorrhoid · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35368-F1	alphafold	PREDICTED	67.40	—

Amino-acid sequence (520 residues)

MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA DVANGQPGFK SNMPLAPGQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards