Piribedil

NERVOUS SYSTEM

Key facts

Piribedil is a drug catalogued in DrugCentral. DrugCentral lists 11 molecular targets, including ADRA2C, ADRA2A and DRD2. Recorded indications include Parkinsonism.

• Molecular targets: ADRA2C, ADRA2A, DRD2 and ADRA1D (11 listed in DrugCentral).
• Indications: Parkinsonism.
• ATC code: N04BC08 (Dopamine agonists).
• Molecular formula: C16H18N4O2; molecular weight 298.35 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Parkinsonism

Mechanism & targets

Molecular targets (11)

Target	Gene	Action	Activity
Alpha-2C adrenergic receptor	ADRA2C	antagonist	Ki 7.20
Alpha-2A adrenergic receptor	ADRA2A	antagonist	Ki 7.10
D(2) dopamine receptor	DRD2	agonist	Ki 6.90
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 6.66
D(3) dopamine receptor	DRD3	agonist	Ki 6.60
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.54
D(4) dopamine receptor	DRD4	antagonist	Ki 6.50
5-hydroxytryptamine receptor 1A	HTR1A	agonist	Ki 6.40
Alpha-1A adrenergic receptor	ADRA1A	antagonist	Ki 6.10
5-hydroxytryptamine receptor 2B	HTR2B	antagonist	Ki 5.90
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 5.21

ATC classification

ATC code	Therapeutic hierarchy
N04BC08	NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › DOPAMINERGIC AGENTS › Dopamine agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Gambling disorder	80.9
Fall	65.9

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Piribedil is on its molecule page.

• Molecular formula: C₁₆H₁₈N₄O₂
• Molecular weight: 298.35 g/mol
• CAS number: 3605-01-4
• InChIKey: OQDPVLVUJFGPGQ-UHFFFAOYSA-N
• PubChem CID: 4850

C(N1CCN(CC1)C1=NC=CC=N1)C1=CC2=C(OCO2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Piribedil used for?

DrugCentral lists the following indications for Piribedil: Parkinsonism.

How does Piribedil work?

Its molecular targets in DrugCentral include ADRA2C (antagonist), ADRA2A (antagonist), DRD2 (agonist) and ADRA1D.

What is the chemical formula of Piribedil?

Piribedil has the molecular formula C16H18N4O2 and a molecular weight of 298.35 g/mol.

Sources

• DrugCentral drug card 2202 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256997 — compound record and bioactivity
• PubChem CID 4850 — chemical identifiers
• DrugBank DB12478 — drug record
• FDA UNII DO22K1PRDJ — substance identity
• UniProt P18825 (ADRA2C) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P25100 (ADRA1D) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P18089 (ADRA2B) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.