Pergolide

Ergot-derived Dopamine Receptor Agonist — NERVOUS SYSTEM

Key facts

Pergolide is an ofm drug in the Ergot-derived Dopamine Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 1988. Its mechanism of action is classified as Dopamine Agonists. DrugCentral lists 34 molecular targets, including DRD3, Htr7 and Drd3. Recorded indications include Parkinsonism.

• Approval status: ofm (first approved 1988 by the FDA).
• Drug class: Ergot-derived Dopamine Receptor Agonist.
• Mechanism of action: Dopamine Agonists.
• Molecular targets: DRD3, Htr7, Drd3 and Drd1|Drd3|Drd5|Drd4|Drd2 (34 listed in DrugCentral).
• Indications: Parkinsonism.
• ATC code: N04BC02 (Dopamine agonists).
• Molecular formula: C19H26N2S; molecular weight 314.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Parkinsonism

Contraindications (12)

• Breastfeeding (mother)
• Conduction disorder of the heart
• Fibrosis of pleura
• Heart valve disorder
• Kidney disease
• Orthostatic hypotension
• Pericardial effusion
• Pericarditis
• Pleural Effusions
• Pleurisy
• Renal fibrosis
• Retroperitoneal fibrosis

Mechanism & targets

• Mechanism of action (MoA): Dopamine Agonists
• Established pharmacologic class: Ergot-derived Dopamine Receptor Agonist

Molecular targets (34)

Target	Gene	Action	Activity
D(3) dopamine receptor	DRD3	agonist	EC50 9.00
5-hydroxytryptamine receptor 7	Htr7	agonist	Ki 9.00
D(3) dopamine receptor	Drd3	unknown	IC50 8.62
Dopamine receptor	Drd1|Drd3|Drd5|Drd4|Drd2	unknown	IC50 8.51
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 8.50
D(2) dopamine receptor	Drd2	unknown	Kd 8.40
D(2) dopamine receptor	DRD2	agonist	EC50 8.30
5-hydroxytryptamine receptor 2B	HTR2B	unknown	EC50 8.20
5-hydroxytryptamine receptor 2A	HTR2A	unknown	EC50 8.10
5-hydroxytryptamine receptor 1D	HTR1D	unknown	Ki 7.90
5-hydroxytryptamine receptor 1A	Htr1a	unknown	IC50 7.82
5-hydroxytryptamine receptor 6	HTR6	unknown	Ki 7.75
Dopamine receptor	DRD2|DRD1	unknown	IC50 7.74
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 7.50
5-hydroxytryptamine receptor 6	Htr6	agonist	Ki 7.50
5-hydroxytryptamine receptor 1B	Htr1b	unknown	Ki 7.40
Cerebral cortex alpha adrenergic receptor	ADRA1A|ADRA2A	unknown	IC50 7.39
Adrenergic receptor alpha-2	Adra2b|Adra2c|Adra2a	unknown	IC50 7.39
D(2) dopamine receptor	DRD2	unknown	IC50 7.32
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 7.30

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1988-12-30	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N04BC02	NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › DOPAMINERGIC AGENTS › Dopamine agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Gambling disorder	124.3

Chemical structure

• Molecular formula: C₁₉H₂₆N₂S
• Molecular weight: 314.50 g/mol
• CAS number: —
• InChIKey: YEHCICAEULNIGD-MZMPZRCHSA-N
• PubChem CID: 47811

CCCN1C[C@H](CSC)C[C@H]2[C@H]1CC1=CNC3=C1C2=CC=C3

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pergolide used for?

DrugCentral lists the following indications for Pergolide: Parkinsonism.

How does Pergolide work?

Pergolide is classified as Dopamine Agonists; its molecular targets in DrugCentral include DRD3 (agonist), Htr7 (agonist), Drd3 and Drd1|Drd3|Drd5|Drd4|Drd2.

When was Pergolide first approved?

Pergolide was first approved by the FDA in 1988.

What drug class does Pergolide belong to?

Pergolide is in the Ergot-derived Dopamine Receptor Agonist class.

What is the chemical formula of Pergolide?

Pergolide has the molecular formula C19H26N2S and a molecular weight of 314.50 g/mol.

Sources

• DrugCentral drug card 2105 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1275 — compound record and bioactivity
• PubChem CID 47811 — chemical identifiers
• DrugBank DB01186 — drug record
• FDA UNII 24MJ822NZ9 — substance identity
• DailyMed: FDA labels for Pergolide — current prescribing information (label search)
• UniProt P35462 (DRD3) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt P28223 (HTR2A) — target protein
• UniProt P28221 (HTR1D) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.