About 5-hydroxytryptamine receptor 1A
5-hydroxytryptamine receptor 1A (HTR1A) is a protein
from Homo sapiens identified by UniProt accession
P08908, 422 residues long.
MolForge cross-references it against 0 known binders and
393 disease associations.
Target properties
| Protein name | 5-hydroxytryptamine receptor 1A |
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| UniProt accession | P08908 |
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| Gene | HTR1A |
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| Organism | Homo sapiens |
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| Length | 422 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (393)
Diseases linked to this target (Open Targets).
- major depressive disorder · score 0.63
- schizophrenia · score 0.62
- anxiety disorder · score 0.61
- bipolar disorder · score 0.61
- unipolar depression · score 0.60
- autism · score 0.60
- schizoaffective disorder · score 0.59
- depressive disorder · score 0.59
- anxiety · score 0.58
- bipolar I disorder · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08908-F1 | alphafold | PREDICTED | 77.81 | — |
Amino-acid sequence (422 residues)
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RQ
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