Alpha-2A adrenergic receptor (ADRA2A)

About Alpha-2A adrenergic receptor

Alpha-2A adrenergic receptor (ADRA2A) is a protein from Homo sapiens identified by UniProt accession P08913, 465 residues long. MolForge cross-references it against 0 known binders and 565 disease associations.

Target properties

Protein name	Alpha-2A adrenergic receptor
UniProt accession	P08913
Gene	ADRA2A
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (565)

Diseases linked to this target (Open Targets).

attention deficit hyperactivity disorder · score 0.61
unipolar depression · score 0.61
pain · score 0.61
Nasal congestion · score 0.60
hypotension · score 0.60
seasonal allergic rhinitis · score 0.60
hypertension · score 0.60
delirium · score 0.60
asthma · score 0.60
Sepsis · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08913-F1	alphafold	PREDICTED	70.18	—

Amino-acid sequence (465 residues)

MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT LVCLAGLLML LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKAW CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIII TVWVISAVIS FPPLISIEKK GGGGGPQPAE PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR RTRVPPSRRG PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR GPGATGIGTP AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LTAVGCSVPR TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards