Atropine

Anticholinergic — ALIMENTARY TRACT AND METABOLISM

Key facts

Atropine is an ofp drug in the Anticholinergic class catalogued in DrugCentral. It was first approved by the FDA in 1960. Its mechanism of action is classified as Cholinergic Antagonists and Cholinergic Muscarinic Antagonists. DrugCentral lists 22 molecular targets, including Chrm3, Muscarinic receptor M1 and Chrm1. Recorded indications include Perioperative Mydriasis.

• Approval status: ofp (first approved 1960 by the FDA).
• Drug class: Anticholinergic; Cholinergic Muscarinic Antagonist.
• Mechanism of action: Cholinergic Antagonists; Cholinergic Muscarinic Antagonists.
• Molecular targets: Chrm3, Muscarinic receptor M1, Chrm1 and Chrm1|Chrm3|Chrm4|Chrm5|Chrm2 (22 listed in DrugCentral).
• Indications: Perioperative Mydriasis.
• ATC code: A03BA01 (Belladonna alkaloids, tertiary amines).
• Molecular formula: C17H23NO3; molecular weight 289.38 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Perioperative Mydriasis

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Antagonists; Cholinergic Muscarinic Antagonists
• Established pharmacologic class: Anticholinergic; Cholinergic Muscarinic Antagonist

Molecular targets (22)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M3	Chrm3	unknown	Ki 9.92
Muscarinic receptor M1	—	unknown	Ki 9.70
Muscarinic acetylcholine receptor M1	Chrm1	unknown	Ki 9.59
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	Ki 9.52
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	Ki 9.50
Muscarinic acetylcholine receptor M2	Chrm2	unknown	Ki 9.46
Acetylcholinesterase	Ache	unknown	Ki 9.46
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 9.39
Muscarinic acetylcholine receptor M1	CHRM1	antagonist	Ki 9.31
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 9.29
Muscarinic acetylcholine receptor M4	Chrm4	unknown	Ki 9.28
Muscarinic acetylcholine receptor M2	Chrm2	unknown	Ki 9.15
Muscarinic acetylcholine receptor M5	Chrm5	unknown	Ki 9.07
Muscarinic acetylcholine receptor	GPM3	unknown	Kd 8.99
Muscarinic acetylcholine receptor M2	CHRM2	antagonist	Ki 8.97
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 6.28
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 6.18
Histamine H1 receptor	HRH1	unknown	Ki 5.91
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.16
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 4.91

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1960-09-15	FDA	—	GD SEARLE LLC

ATC classification

ATC code	Therapeutic hierarchy
A03BA01	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › BELLADONNA AND DERIVATIVES, PLAIN › Belladonna alkaloids, tertiary amines
A03CB03	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Belladonna and derivatives in combination with psycholeptics
S01FA01	SENSORY ORGANS › OPHTHALMOLOGICALS › MYDRIATICS AND CYCLOPLEGICS › Anticholinergics
V03AB54	VARIOUS › ALL OTHER THERAPEUTIC PRODUCTS › ALL OTHER THERAPEUTIC PRODUCTS › Antidotes

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Macular degeneration	307.4
Death	235.9
Stress cardiomyopathy	226.3
Bradycardia	208.3
Cardiac arrest	200.2
Anticholinergic syndrome	190.9
Hypotension	172.0
Dehydration	136.6
Therapy interrupted	134.2
Mydriasis	124.9
Paraesthesia oral	117.0
Diarrhoea	114.4

Chemical structure

• Molecular formula: C₁₇H₂₃NO₃
• Molecular weight: 289.38 g/mol
• CAS number: 51-55-8
• InChIKey: RKUNBYITZUJHSG-SPUOUPEWSA-N
• PubChem CID: 174174

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Atropine used for?

DrugCentral lists the following indications for Atropine: Perioperative Mydriasis.

How does Atropine work?

Atropine is classified as Cholinergic Antagonists and Cholinergic Muscarinic Antagonists; its molecular targets in DrugCentral include Chrm3, Muscarinic receptor M1, Chrm1 and Chrm1|Chrm3|Chrm4|Chrm5|Chrm2.

When was Atropine first approved?

Atropine was first approved by the FDA in 1960.

What drug class does Atropine belong to?

Atropine is in the Anticholinergic class.

What is the chemical formula of Atropine?

Atropine has the molecular formula C17H23NO3 and a molecular weight of 289.38 g/mol.

Sources

• DrugCentral drug card 260 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2146146 — compound record and bioactivity
• PubChem CID 174174 — chemical identifiers
• DrugBank DB00572 — drug record
• FDA UNII 7C0697DR9I — substance identity
• DailyMed: FDA labels for Atropine — current prescribing information (label search)
• UniProt P20309 (CHRM3) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P28335 (HTR2C) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.