About Solute carrier family 22 member 1
Solute carrier family 22 member 1 (SLC22A1) is a protein
from Homo sapiens identified by UniProt accession
O15245, 554 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 1 |
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| UniProt accession | O15245 |
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| Gene | SLC22A1 |
|---|
| Organism | Homo sapiens |
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| Length | 554 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (170)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.49
- bilirubin measurement · score 0.48
- total cholesterol measurement · score 0.48
- serum metabolite measurement · score 0.47
- triglyceride measurement · score 0.46
- apolipoprotein B measurement · score 0.45
- IGF-1 measurement · score 0.44
- blood metabolite measurement · score 0.44
- urinary metabolite measurement · score 0.43
- Hypercholesterolemia · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15245-F1 | alphafold | PREDICTED | 84.23 | — |
Amino-acid sequence (554 residues)
MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE PSGT
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