Quinine

Antimalarial — MUSCULO-SKELETAL SYSTEM

Key facts

Quinine is an ofp drug in the Antimalarial class catalogued in DrugCentral. It was first approved by the FDA in 2005. DrugCentral lists 7 molecular targets, including SCN1A|SCN2A|SCN3A, ABCB1 and KCNB2. Recorded indications include Chloroquine Resistant Plasmodium Falciparum Malaria and Falciparum malaria.

• Approval status: ofp (first approved 2005 by the FDA).
• Drug class: Antimalarial.
• Molecular targets: SCN1A|SCN2A|SCN3A, ABCB1, KCNB2 and SLC29A4 (7 listed in DrugCentral).
• Indications: Chloroquine Resistant Plasmodium Falciparum Malaria and Falciparum malaria.
• ATC code: M09AA72 (Quinine and derivatives).
• Molecular formula: C20H24N2O2; molecular weight 324.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Chloroquine Resistant Plasmodium Falciparum Malaria
• Falciparum malaria

Off-label uses (1)

• Babesiosis

Contraindications (17)

• Acute nephropathy
• Anemia due to enzyme deficiency
• Atrial fibrillation
• Atrial flutter
• Black water fever
• Congenital long QT syndrome
• Disease of liver
• End stage renal disease
• Hemolytic uremic syndrome
• Hypoglycemic disorder
• Myasthenia gravis
• Neuromuscular block, function
• Optic neuritis
• Prolonged QT interval
• Thrombocytopenic disorder
• Thrombotic thrombocytopenic purpura
• Torsades de pointes

Mechanism & targets

• Established pharmacologic class: Antimalarial

Molecular targets (7)

Target	Gene	Action	Activity
Sodium channel alpha subunits; brain (Types I, II, III)	SCN1A|SCN2A|SCN3A	unknown	IC50 5.36
Multidrug resistance protein 1	ABCB1	unknown	Ki 4.92
Potassium voltage-gated channel subfamily B member 2	KCNB2	blocker	IC50 4.90
Equilibrative nucleoside transporter 4	SLC29A4	inhibitor	Ki 4.57
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 4.29
Hemoglobin subunit alpha	HBA1	unknown	—
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2005-08-12	FDA	—	MUTUAL PHARM CO INC

ATC classification

ATC code	Therapeutic hierarchy
M09AA72	MUSCULO-SKELETAL SYSTEM › OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM › OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM › Quinine and derivatives
P01BC01	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › ANTIMALARIALS › Methanolquinolines

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: G6PD · Actionable PGx
• FDA label: CYP2D6
• HCSC label: G6PD · Actionable PGx
• Swissmedic label: G6PD · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug abuse	1541.1
Toxicity to various agents	438.8
Sedation complication	184.1
Thrombotic microangiopathy	178.0
Labile blood pressure	153.7
Cinchonism	126.8
Blood calcium decreased	122.0
Creatinine renal clearance decreased	121.7
Renal function test abnormal	120.1
Creatinine renal clearance increased	119.0
Somatic symptom disorder	115.6
Cognitive disorder	109.4

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Quinine is on its molecule page.

• Molecular formula: C₂₀H₂₄N₂O₂
• Molecular weight: 324.42 g/mol
• CAS number: —
• InChIKey: LOUPRKONTZGTKE-WZBLMQSHSA-N
• PubChem CID: 3034034

COC1=CC=C2N=CC=C([C@@H](O)[C@@H]3C[C@@H]4CC[N@]3C[C@@H]4C=C)C2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Quinine used for?

DrugCentral lists the following indications for Quinine: Chloroquine Resistant Plasmodium Falciparum Malaria and Falciparum malaria.

How does Quinine work?

Its molecular targets in DrugCentral include SCN1A|SCN2A|SCN3A, ABCB1, KCNB2 (blocker) and SLC29A4 (inhibitor).

When was Quinine first approved?

Quinine was first approved by the FDA in 2005.

What drug class does Quinine belong to?

Quinine is in the Antimalarial class.

What is the chemical formula of Quinine?

Quinine has the molecular formula C20H24N2O2 and a molecular weight of 324.42 g/mol.

Sources

• DrugCentral drug card 4523 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL170 — compound record and bioactivity
• PubChem CID 3034034 — chemical identifiers
• DrugBank DB00468 — drug record
• FDA UNII A7V27PHC7A — substance identity
• DailyMed: FDA labels for Quinine — current prescribing information (label search)
• UniProt P08183 (ABCB1) — target protein
• UniProt Q92953 (KCNB2) — target protein
• UniProt Q7RTT9 (SLC29A4) — target protein
• UniProt O15245 (SLC22A1) — target protein
• UniProt P69905 (HBA1) — target protein
• UniProt Q12809 (KCNH2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.