Hemoglobin subunit alpha (HBA1)

About Hemoglobin subunit alpha

Hemoglobin subunit alpha (HBA1) is a protein from Homo sapiens identified by UniProt accession P69905, 142 residues long. MolForge cross-references it against 0 known binders and 317 disease associations.

Target properties

Protein name	Hemoglobin subunit alpha
UniProt accession	P69905
Gene	HBA1
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (317)

Diseases linked to this target (Open Targets).

Alpha-thalassemia · score 0.75
hemoglobin H disease · score 0.73
alpha thalassemia spectrum · score 0.70
Heinz body anemia · score 0.70
Autosomal dominant methemoglobinemia · score 0.65
primary familial polycythemia due to EPO receptor mutation · score 0.59
mean corpuscular volume · score 0.59
mean corpuscular hemoglobin · score 0.59
sickle cell anemia · score 0.58
beta thalassemia · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P69905-F1	alphafold	PREDICTED	98.06	—

Amino-acid sequence (142 residues)

MVLSPADKTN VKAAWGKVGA HAGEYGAEAL ERMFLSFPTT KTYFPHFDLS HGSAQVKGHG KKVADALTNA VAHVDDMPNA LSALSDLHAH KLRVDPVNFK LLSHCLLVTL AAHLPAEFTP AVHASLDKFL ASVSTVLTSK YR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards