Equilibrative nucleoside transporter 4 (SLC29A4)
Homo sapiens — UniProt Q7RTT9
Data last refreshed: (UniProt release unknown)
Key facts
Equilibrative nucleoside transporter 4 (SLC29A4) is a protein from Homo sapiens identified by UniProt accession Q7RTT9, 530 residues long. MolForge cross-references it against 6 known binders and 112 disease associations.
- UniProt accession: Q7RTT9; gene symbol SLC29A4.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Target class: Transporter.
- Approved drugs acting on it (DrugCentral): Dipyridamole, Verapamil, Fluoxetine, Quinidine and Quinine and others.
- Top disease associations (Open Targets): neurodegenerative disease, visual perception measurement and Hashimoto's thyroiditis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Equilibrative nucleoside transporter 4 |
|---|---|
| UniProt accession | Q7RTT9 |
| Gene | SLC29A4 |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (6)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (112)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- visual perception measurement · score 0.21
- Hashimoto's thyroiditis · score 0.16
- body height · score 0.15
- cutaneous melanoma · score 0.12
- dermatitis · score 0.11
- mean platelet volume · score 0.10
- hypothyroidism · score 0.10
- congenital radioulnar synostosis · score 0.08
- erythrocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7RTT9-F1 | alphafold | PREDICTED | 74.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7RTT9.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SLC29A4?
DrugCentral lists 6 approved drugs whose mechanism of action is SLC29A4: Dipyridamole, Verapamil, Fluoxetine, Quinidine, Quinine and Desipramine.
Which diseases are associated with SLC29A4?
The strongest Open Targets associations for SLC29A4 are neurodegenerative disease, visual perception measurement, Hashimoto's thyroiditis, body height and cutaneous melanoma.
How long is the SLC29A4 protein?
The Homo sapiens SLC29A4 protein (UniProt Q7RTT9) is 530 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7RTT9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7RTT9 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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