Chlorprothixene

NERVOUS SYSTEM

Key facts

Chlorprothixene is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1967. DrugCentral lists 18 molecular targets, including HTR2A, DRD4 and Hrh1. Recorded indications include Schizophrenia.

• Approval status: ofm (first approved 1967 by the FDA).
• Molecular targets: HTR2A, DRD4, Hrh1 and DRD2 (18 listed in DrugCentral).
• Indications: Schizophrenia.
• ATC code: N05AF03 (Thioxanthene derivatives).
• Molecular formula: C18H18ClNS; molecular weight 315.86 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Schizophrenia

Contraindications (20)

• Agranulocytosis
• Alcohol withdrawal syndrome
• Angle-closure glaucoma
• Benign prostatic hyperplasia
• Breastfeeding (mother)
• Carcinoma of female breast
• Coma
• Disease of blood AND/OR blood-forming organ
• Disorder of cardiovascular system
• Drug Induced CNS Depression
• Epilepsy
• Leukopenia
• Neuroleptic malignant syndrome
• Neutropenic disorder
• Parkinsonism
• Retention of urine
• Senile dementia
• Shock
• Stupor
• Tardive dyskinesia

Mechanism & targets

Molecular targets (18)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 9.37
D(4) dopamine receptor	DRD4	unknown	Ki 9.19
Histamine H1 receptor	Hrh1	unknown	IC50 8.97
D(2) dopamine receptor	DRD2	antagonist	Ki 8.53
5-hydroxytryptamine receptor 6	HTR6	unknown	Ki 8.52
Histamine H1 receptor	HRH1	unknown	Ki 8.43
D(3) dopamine receptor	DRD3	antagonist	Ki 8.34
5-hydroxytryptamine receptor 7	Htr7	unknown	Ki 8.25
D(1B) dopamine receptor	DRD5	unknown	Ki 8.05
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 7.96
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 7.75
D(1A) dopamine receptor	DRD1	unknown	Ki 7.74
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 7.66
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 7.60
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.55
Pleiotropic ABC efflux transporter of multiple drugs	PDR5	unknown	IC50 5.29
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 4.38
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 4.11

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1967-06-19	FDA	—	ROCHE

ATC classification

ATC code	Therapeutic hierarchy
N05AF03	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Thioxanthene derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxicity to various agents	203.2
Neuroleptic malignant syndrome	198.6
Intentional overdose	141.3
Intentional self-injury	141.2
Drug interaction	133.8
Suicide attempt	117.9
Serotonin syndrome	114.3
Suicidal ideation	110.0
Extrapyramidal disorder	91.1
Restlessness	83.8
Akathisia	77.5
Ileus paralytic	67.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Chlorprothixene is on its molecule page.

• Molecular formula: C₁₈H₁₈ClNS
• Molecular weight: 315.86 g/mol
• CAS number: 113-59-7
• InChIKey: WSPOMRSOLSGNFJ-AUWJEWJLSA-N
• PubChem CID: 667467

CN(C)CC\C=C1\C2=CC=CC=C2SC2=C1C=C(Cl)C=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Chlorprothixene used for?

DrugCentral lists the following indications for Chlorprothixene: Schizophrenia.

How does Chlorprothixene work?

Its molecular targets in DrugCentral include HTR2A, DRD4, Hrh1 and DRD2 (antagonist).

When was Chlorprothixene first approved?

Chlorprothixene was first approved by the FDA in 1967.

What is the chemical formula of Chlorprothixene?

Chlorprothixene has the molecular formula C18H18ClNS and a molecular weight of 315.86 g/mol.

Sources

• DrugCentral drug card 623 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256658 — compound record and bioactivity
• PubChem CID 667467 — chemical identifiers
• DrugBank DB01239 — drug record
• FDA UNII 9S7OD60EWP — substance identity
• DailyMed: FDA labels for Chlorprothixene — current prescribing information (label search)
• UniProt P28223 (HTR2A) — target protein
• UniProt P21917 (DRD4) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P50406 (HTR6) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt P35462 (DRD3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.