D(2) dopamine receptor (DRD2)

About D(2) dopamine receptor

D(2) dopamine receptor (DRD2) is a protein from Homo sapiens identified by UniProt accession P14416, 443 residues long. MolForge cross-references it against 0 known binders and 811 disease associations.

Target properties

Protein name	D(2) dopamine receptor
UniProt accession	P14416
Gene	DRD2
Organism	Homo sapiens
Length	443 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (811)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.73
bipolar disorder · score 0.72
unipolar depression · score 0.71
major depressive disorder · score 0.70
attention deficit hyperactivity disorder · score 0.66
Tourette syndrome · score 0.65
Parkinson disease · score 0.62
autism · score 0.62
psychosis · score 0.61
obsessive-compulsive disorder · score 0.61

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14416-F1	alphafold	PREDICTED	72.45	—

Amino-acid sequence (443 residues)

MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards