Dordaviprone

Protease Activator

Key facts

Dordaviprone is an onp drug in the Protease Activator class catalogued in DrugCentral. It was first approved by the FDA in 2025. Its mechanism of action is classified as Protease Activators. DrugCentral lists 3 molecular targets, including CLPP, DRD3 and DRD2. Recorded indications include Diffuse midline glioma (H3 K27M mutation) .

• Approval status: onp (first approved 2025 by the FDA).
• Drug class: Protease Activator.
• Mechanism of action: Protease Activators.
• Molecular targets: CLPP, DRD3 and DRD2 (3 listed in DrugCentral).
• Indications: Diffuse midline glioma (H3 K27M mutation) .
• Molecular formula: C24H26N4O; molecular weight 386.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Diffuse midline glioma (H3 K27M mutation)

Mechanism & targets

• Mechanism of action (MoA): Protease Activators
• Established pharmacologic class: Protease Activator

Molecular targets (3)

Target	Gene	Action	Activity
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	activator	EC50 4.90
D(3) dopamine receptor	DRD3	antagonist	Ki 4.55
D(2) dopamine receptor	DRD2	antagonist	Ki 4.18

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-08-06	FDA	—	CHIMERIX	Yes

Chemical structure

• Molecular formula: C₂₄H₂₆N₄O
• Molecular weight: 386.50 g/mol
• CAS number: —
• InChIKey: VLULRUCCHYVXOH-UHFFFAOYSA-N
• PubChem CID: 73777259

CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dordaviprone used for?

DrugCentral lists the following indications for Dordaviprone: Diffuse midline glioma (H3 K27M mutation) .

How does Dordaviprone work?

Dordaviprone is classified as Protease Activators; its molecular targets in DrugCentral include CLPP (activator), DRD3 (antagonist) and DRD2 (antagonist).

When was Dordaviprone first approved?

Dordaviprone was first approved by the FDA in 2025.

What drug class does Dordaviprone belong to?

Dordaviprone is in the Protease Activator class.

What is the chemical formula of Dordaviprone?

Dordaviprone has the molecular formula C24H26N4O and a molecular weight of 386.50 g/mol.

Sources

• DrugCentral drug card 5780 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4297310 — compound record and bioactivity
• PubChem CID 73777259 — chemical identifiers
• DrugBank DB14844 — drug record
• FDA UNII 9U35A31JAI — substance identity
• DailyMed: FDA labels for Dordaviprone — current prescribing information (label search)
• UniProt Q16740 (CLPP) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P14416 (DRD2) — target protein

How this page is built: methodology · editorial policy & corrections.