Oliceridine

NERVOUS SYSTEM

Key facts

Oliceridine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 2020. DrugCentral lists 9 molecular targets, including OPRM1, OPRL1 and CYP2D6. Recorded indications include Moderate pain and Severe pain.

• Approval status: ofm (first approved 2020 by the FDA).
• Molecular targets: OPRM1, OPRL1, CYP2D6 and SCN5A (9 listed in DrugCentral).
• Indications: Moderate pain and Severe pain.
• ATC code: N02AX07 (Other opioids).
• Molecular formula: C22H30N2O2S; molecular weight 386.55 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Moderate pain
• Severe pain

Contraindications (4)

• Asthma
• Decreased respiratory function
• Gastrointestinal obstruction
• Paralytic ileus

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Mu-type opioid receptor	OPRM1	agonist	Ki 8.22
Nociceptin receptor	OPRL1	agonist	EC50 7.40
Cytochrome P450 2D6	CYP2D6	unknown	IC50 5.34
Sodium channel protein type 5 subunit alpha	SCN5A	unknown	IC50 5.33
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 5.21
D(3) dopamine receptor	DRD3	unknown	Ki 5.16
Cytochrome P450 3A4	CYP3A4	unknown	IC50 4.87
Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	unknown	IC50 4.44
D(2) dopamine receptor	DRD2	unknown	Ki 4.08

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2020-08-07	FDA	—	TREVENA INC

ATC classification

ATC code	Therapeutic hierarchy
N02AX07	NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Other opioids

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• EMA label
• FDA label: CYP2D6 · Actionable PGx
• HCSC label

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oliceridine is on its molecule page.

• Molecular formula: C₂₂H₃₀N₂O₂S
• Molecular weight: 386.55 g/mol
• CAS number: 1401028-24-7
• InChIKey: DMNOVGJWPASQDL-OAQYLSRUSA-N
• PubChem CID: 66553195

COC1=C(SC=C1)CNCC[C@]2(CCOC3(C2)CCCC3)C4=CC=CC=N4

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oliceridine used for?

DrugCentral lists the following indications for Oliceridine: Moderate pain and Severe pain.

How does Oliceridine work?

Its molecular targets in DrugCentral include OPRM1 (agonist), OPRL1 (agonist), CYP2D6 and SCN5A.

When was Oliceridine first approved?

Oliceridine was first approved by the FDA in 2020.

What is the chemical formula of Oliceridine?

Oliceridine has the molecular formula C22H30N2O2S and a molecular weight of 386.55 g/mol.

Sources

• DrugCentral drug card 5406 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2443262 — compound record and bioactivity
• PubChem CID 66553195 — chemical identifiers
• DrugBank DB14881 — drug record
• FDA UNII MCN858TCP0 — substance identity
• DailyMed: FDA labels for Oliceridine — current prescribing information (label search)
• UniProt P35372 (OPRM1) — target protein
• UniProt P41146 (OPRL1) — target protein
• UniProt P10635 (CYP2D6) — target protein
• UniProt Q14524 (SCN5A) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt P35462 (DRD3) — target protein
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.