Mu-type opioid receptor (OPRM1)

About Mu-type opioid receptor

Mu-type opioid receptor (OPRM1) is a protein from Homo sapiens identified by UniProt accession P35372, 400 residues long. MolForge cross-references it against 0 known binders and 609 disease associations.

Target properties

Protein name	Mu-type opioid receptor
UniProt accession	P35372
Gene	OPRM1
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (609)

Diseases linked to this target (Open Targets).

opioid use disorder · score 0.68
cancer · score 0.62
opioid dependence · score 0.62
drug dependence · score 0.61
alcohol dependence · score 0.61
pain · score 0.61
Chronic pain · score 0.61
migraine disorder · score 0.61
Diarrhea · score 0.61
Constipation · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35372-F1	alphafold	PREDICTED	76.57	—

Amino-acid sequence (400 residues)

MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards