Tilidine

NERVOUS SYSTEM

Key facts

Tilidine is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1970. DrugCentral lists 1 molecular target, including OPRM1. Recorded indications include Pain.

• Molecular targets: OPRM1 (1 listed in DrugCentral).
• Indications: Pain.
• ATC code: N02AX01 (Other opioids).
• Molecular formula: C17H23NO2; molecular weight 273.38 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Pain

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Mu-type opioid receptor	OPRM1	agonist	EC50 5.10

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1970-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N02AX01	NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Other opioids
N02AX51	NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Other opioids

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Brain oedema	224.5
Pulmonary oedema	137.0
Toxicity to various agents	112.9
Respiratory depression	84.7
Hepatitis E antibody positive	82.2
Hepatitis E virus test positive	80.2
Suspected transmission of an infectious agent via product	64.4
Psychiatric decompensation	46.6
Hydrocholecystis	40.7
VACTERL syndrome	40.6
Poisoning	40.0
Substance abuse	38.8

Chemical structure

• Molecular formula: C₁₇H₂₃NO₂
• Molecular weight: 273.38 g/mol
• CAS number: —
• InChIKey: WDEFBBTXULIOBB-UHFFFAOYSA-N
• PubChem CID: 30131

CCOC(=O)C1(CCC=CC1N(C)C)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tilidine used for?

DrugCentral lists the following indications for Tilidine: Pain.

How does Tilidine work?

Its molecular targets in DrugCentral include OPRM1 (agonist).

When was Tilidine first approved?

Tilidine was first approved by the YEAR INTRODUCED in 1970.

What is the chemical formula of Tilidine?

Tilidine has the molecular formula C17H23NO2 and a molecular weight of 273.38 g/mol.

Sources

• DrugCentral drug card 2663 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2218854 — compound record and bioactivity
• PubChem CID 30131 — chemical identifiers
• DrugBank DB13787 — drug record
• FDA UNII GY33N31E9Y — substance identity
• UniProt P35372 (OPRM1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.